Sinan Cem UZUNGET, Zamir Kemal ERTÜRK, Sevinç BAYRAK, Hidayet Can ÜNAL, Mustafa Hamidullah TÜRKKANI

Acil Servise Başvuran COVID-19 Hastalarında Mukosiliyer Klirensin İncelenmesi

Öz Solunum yolu epitelinde yer alan mukosiliyer tabaka, solunum yollarındaki ilk koruma mekanizması olarak görev yapmaktadır. Şiddetli akut solunum sendromu koronavirus-2 de (SARS-Cov-2), diğer bazı solunum yolu virüsleri gibi siliyer hücrelere yapışmakta ve mukosilier aktiviteyi etkilemektedir. Sakkarin testi ile mukosilier klirensin ölçülmesi mümkündür. Çalışmamızda acil servise başvuran hastalarda SARS-CoV 2 ye bağlı olarak gelişen Korona virus hastalığı-2019 (COVİD-19) enfeksiyonunda erken dönemde mukosiliyer klirensin etkisini değerlendirmeyi amaçladık Gereç ve Yöntem: Acil servise başvuran ve son 48 saat içerisinde COVID-19 düşündüren yakınmaları olan ve Polimeraz zincir reaksiyonu (PCR) testi çalışılan 84 kişilik hasta grubunda mukosilier klirens zamanı (MCT), sakkarin testi ile ölçülerek sağlıklı gönüllülerde yapılan ölçüm ile karşılaştırılmıştır. Sonuçlar PCR pozitif olarak tespit edilen katılmcılarda ortalama MCT 14.58 dakika olarak, sağlıklı gönüllülerde ise ortalama MCT 13.72 dakika olarak ölçüldü. İki grup arasında istatistiksel açıdan fark saptanmadı (p=0,657). Tartışma COVID-19 etkeni olan SARS-CoV-2’nin solunum yolu epiteli hasarı yaptığı ve solunum yollarında hastalık oluşturduğu bilinmektedir. Erken dönemde yapılan PCR testlerinde üst solunum yolu mukozasında tespit edilmekle beraber, erken dönemde MCT üzerine etkisi bulunmamaktadır.

Anahtar Kelimeler:

COVID-19, Mukosiliyer klirens, sakkarin testi

Evaluation of Mucociliary Clearance in COVID-19 Patients Presenting to the Emergency Department

Abstract The mucociliary layer in the respiratory epithelium acts as the first protective mechanism in the respiratory tract. Severe acute respiratory syndrome coronavirus-2 (SARS-Cov-2) also adheres to ciliary cells and affects mucociliary activity, like some other respiratory viruses. It is possible to measure mucociliary clearance with the saccharine test. In our study, we aimed to evaluate the effect of mucociliary clearance in the early period of Corona virus disease-2019 (COVID-19) infection due to SARS-CoV 2 in patients admitted to the emergency department. Methods Mucociliary clearance time (MCT) was measured with the saccharin test and compared with the measurement made in healthy volunteers in a group of 84 patients who applied to the emergency department and had symptoms suggestive of COVID-19 in the last 48 hours and whose Polymerase chain reaction (PCR) test was studied. Results Mean MCT was measured as 14.58 minutes in PCR positive participants and 13.72 minutes in healthy volunteers. There was no statistical difference between the two groups (p=0.657). Conclusion It is known that SARS-CoV-2, which is the cause of COVID-19, causes respiratory tract epithelial damage and causes diseases in the respiratory tract. Although it is detected in the upper respiratory tract mucosa in early PCR tests, it is thought to have no effect on MCT in the early period.

Keywords:

COVID-19, Mukosiliyer klirens, sakkarin testi,

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