This study describes the optimal conditions for the determination of Thioridazine HCl (Tz-HCl) in 0.2 M sulphuric acid by voltammetry using ruthenium (Ru), platinum (Pt) and glassy carbon (GC) electrodes. A new and sensitive method is described for electrochemical determination of Tz-HCl in the concentration range 5.10-5 - 10-3 M (20.35-407 mgml-1); 6.10-4 - 10-2 M (244.2 - 4070 mgml-1); 10-4 - 10-3 M (40,7 - 407 mgml-1), with Ru, Pt and glassy carbon electrodes, respectively. The method was applied successfully to the determination of Tz-HCl in pure form or incorporated in their representative pharmaceutical preparations. The precision of the assay was comparable with that of the official assays.

This study describes the optimal conditions for the determination of Thioridazine HCl (Tz-HCl) in 0.2 M sulphuric acid by voltammetry using ruthenium (Ru), platinum (Pt) and glassy carbon (GC) electrodes. A new and sensitive method is described for electrochemical determination of Tz-HCl in the concentration range 5.10-5 - 10-3 M (20.35-407 mgml-1); 6.10-4 - 10-2 M (244.2 - 4070 mgml-1); 10-4 - 10-3 M (40,7 - 407 mgml-1), with Ru, Pt and glassy carbon electrodes, respectively. The method was applied successfully to the determination of Tz-HCl in pure form or incorporated in their representative pharmaceutical preparations. The precision of the assay was comparable with that of the official assays.