Eldar GASIMOV, Zarema GAKHRAMANOVA, Abel MAHARRAMOV, Goncha EYVAZOVA, Aygun ISRAYILOVA, Sarvinaz HAJIYEVA, Fuad RZAYEV, Khudaverdi GANBAROV, Gunel ALIYEV, Ulviyya HASANOVA, Alakbar HUSEYNZADA, Ilaha HASANOVA

The role of diazacrown ether in the enhancement of the biological activity of silver nanoparticles

The nanostructuring of hydroxyl-substituted diazacrown-ether (DC) by silver nanoparticles was obtainedby green synthesis method in order to increase the antibacterial activity of silver nanoparticles. The synthesized DC, nanoparticles, and nanosupramolecular complex (Ag@DC) were studied by TEM, powder-XRD, and NMR, IR, and UV spectroscopy methods. The Ag@DC nanostructures were uniform and their sizes ranged from 8 to 18 nm. IR and UV spectra revealed the noncovalent formation of the nanosupramolecular complex. The antibacterial activities of the prepared active agents were investigated on gram-positive and gram-negative bacteria by twofold microdilution method. Ultrastructural study by TEM was performed on E. coli BDU12 after treatment with Ag@DC. The results showed the improvement of the antibacterial action of Ag@DC compared to silver nanoparticles (E. coli BDU12 – 32 times, A. baumannii BDU32 – 16 times, K. pneumoniae BDU44 and P. aeruginosa BDU49 – 4 times, S. aureus BDU23 – 512 times). Chelating by DC significantly improved the antibacterial effects of the silver nanoparticles on gram-positive and gram-negative bacteria due to the ionophoric behavior of the crown ethers.

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