The interaction between a zinc(II) phthalocyanine compound bearing octakis phenoxyacetamide substituents and calf thymus DNA
In this study, a zinc(II) phthalocyanine compound
(PcZn) substituted with octakis phenoxyacetamide was synthesized
and characterized. Calf thymus DNA (CT-DNA) was used to determine the DNA
binding properties of the zinc(II) phthalocyanine compound. This interaction
of CT-DNA with PcZn was investigated using electronic absorption
spectra, emission spectroscopy, a thermal melting temperature study, cyclic
voltammetry, and viscosity measurements in a Tris-HCl buffer solution at a
pH of 7.2. The findings showed that zinc(II) phthalocyanine interacts with
calf thymus DNA via partial intercalative binding mechanisms. In addition to
the techniques above, a gel electrophoresis study was also carried out to
verify the interaction of CT-DNA with the PcZn complex. The results
demonstrated that the octakis phenoxyacetamide-substituted zinc(II)
phthalocyanine complex binds to CT-DNA via a partial intercalative binding
mode.
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