Kamal M. DAWOOD, Eman A. RAGAB, Korany A. ALI

7578

Synthetic access to some new benzothiazole-based 1,3,4-thiadiazole and1,3-thiazole derivatives

Synthetic access to some new benzothiazole-based 1,3,4-thiadiazole and1,3-thiazole derivatives

1-(Benzothiazol-2-yl)-3-phenylthiourea2was prepared and treated with hydrazonoyl chlorides3a{etoyield the corresponding 5-(benzothiazol-2-ylimino)-1,3,4-thiadiazole derivatives6a{e, respectively. Reaction of thethiourea derivative2with ethyl 2-chloro-3-oxobutanoate9afforded the corresponding 2-(benzothiazol-2-ylimino)thiazole-5-carboxylate derivative11. The newly synthesized heterocyclic derivatives were con rmed from their elemental andspectral analyses.
PDF

___

  • 1.Padmavathi, V.; Reddy, G. S.; Padmaja, A.; Kondaiah, P.; Shazia, A.Eur. J. Med. Chem.2009,44, 2106{2112.
  • 2.Dawood, K. M.; Eldebss, T. M. A.; El-Zahabi, H. S.; Yousef, M. H.; Metz, P.Eur. J. Med. Chem.2013,70,740{749.
  • 3.Juszczak, M.; Matysiak, J.; Szeliga, M.; Pozarowski, P.; Rzeski, W.Bioorg. Med. Chem. Lett.2012,22, 5466{5469.
  • 4.Khan, I.; Ali, S.: Hameed, S.; Rama, N. H.; Hussain, M. T.; Wadood, A.; Uddin, R.; Ul-Haq, Z.; Khan, A.; Ali,S.; et al.Eur. J. Med. Chem.2010,45, 5200{5207.
  • 5.Jubie, S.; Ramesh, P. N.; Dhanabal, P.; Kalirajana, R.; Murugananthamb, N.; Antonyc, A. S.Eur. J. Med. Chem.2012,54, 931{935.
  • 6.Dawood, K. M.; Abdel-Gawad, H.; Ragab, E. A.; Ellithey, M.; Mohamed, H. A.Bioorg. Med. Chem.2006,14,3672{3680.
  • 7.Harish, K. P.; Mohana, K. N.; Mallesha, L. S.Drug Invent. Today2013,5, 92{99.
  • 8.Hasui, T.; Matsunaga, N.; Ora, T.; Ohyabu, N.; Nishigaki, N.; Imura, Y.; Igata, Y.; Matsui, H.; Motoyaji, T.;Habuka, N.; et al.J. Med. Chem.2011,54, 8616{8631.
  • 9.Skrzypek, A.; Matysiak, J.; Karpinska, M. M.; Niewiadomy, A.Enzyme Inhib. Med. Chem.2013,28, 816{823.
  • 10.Skrzypek, A.; Matysiak, J.; Niewiadomy, A.; Bajda, M.; Szymanski, P.Eur. J. Med. Chem.2013,62, 311{319.
  • 11.Dhooghe, M.; De Kime, N.Tetrahedron2006,62, 513{536.
  • 12.Galabov, A. S.; Galabov, B. S.; Neykova, N. A.J.Med. Chem.1980,23, 1048{1051.
  • 13.Hunter, R.; Younis, Y.; Muhanji, C. I.; Curtin, T. L.; Naidoo, K. J.; Petersen, M.; Bailey, C. M.; Basavapathruni,A.; Anderson, K. S.Bioorg. Med. Chem.2008,16, 10270{10280.
  • 14.Abdel-Aziem, A.; El-Gendy, M. S.; Abdelhamid, A. O.Eur. J. Chem.2012,3, 455{460.
  • 15.Lv, P. C.; Li, H. Q.; Sun, J.; Zhou, Y.; Zhu, H. L.Bioorg. Med. Chem.2010,18, 4606{4614.
  • 16.Bahekar, S. S.; Shinde, D. B.J. Korean Chem. Soc.2003, 47, 237{240.
  • 17.Saeed, A.; Ra que, H.; Hameed, A.; Rasheed, S. Pharm. Chem. J.,2008,42,191{195.
  • 18.Kumbhare, R. M.; Dadmal, T.; Kosurkar, U.; Sridhar, V.; Rao, J. V.Bioorg. Med. Chem. Lett.2012,22, 453{455.
  • 19.Abdel-Rahman, H. M.; Morsy, M. A.J. Enzym. Inhib. Med. Chem.2007,22,57{64.
  • 20.Dawood, K. M.; Abu-Deif, H. K.Chem. Pharm. Bull.2014,62, 439{445.
  • 21.Dawood, K. M.; Abu-Deif, H. K.Eur. J. Chem.2013,4, 277{284.
  • 22.Dawood, K. M.; Abdel-Gawad, H.; Mohamed, H. A.; Badria, F. A.Med. Chem. Res.2011,20, 912{919.
  • 23.Hegazi, B.; Mohamed, H. A.; Dawood, K. M.; Badria, F. A. R.Chem. Pharm. Bull.2010,58, 479{483.
  • 24.Abdel-Gawad, H.; Mohamed, H. A.; Dawood, K. M.; Badria, F. A. R.Chem. Pharm. Bull.2010,58, 1529{1531.
  • 25.Dawood, K. M.; Ragab, E. A.; Farag, A. M.Phosphrus, Sulfur and Silicon2010,185, 1796{17802.
  • 26.Dawood, K. M.; Raslan, M. A.J. Heterocycl. Chem.2008,45, 137{141.
  • 27.Dawood, K. M.; Farag, A. M.; Abdelaziz, H. A.Heteroatom Chem.2007,18, 294{300.
  • 28.Dawood, K. M.; Farag, A. M.; Abdelaziz, H. A.Heteroatom Chem.2005,16, 621{627.
  • 29.Farag, A. M.; Dawood, K. M.; Elmenoufy, H. A.Heteroatom Chem.2004,15, 508{514.
  • 30.Dawood, K. M.; Ragab, E. A.; Farag, A. M.J. Chem Res.2003,(S)685{586,(M) 1151{1160.
  • 31.Dawood, K. M.; Raslan, M. A.; Farag, A. M.Synth. Commun.2003,33, 4079{4086.
  • 32.Kandeel, Z. E.; Dawood, K. M.; Ragab, E. A.; Farag, A. M.Heteroatom Chem.2002,13, 248{251.
  • 33.Glotova, T. E.; Dvorko, M. Yu.; Albanov, A. I.; Kazheva, O. N.; Shilov, G. V.; D'yachenko, O. A.Russ. J. Org.Chem.2008,44, 1532{1537.
  • 34.Kumbhare, R. M.; Dadmal, T.; Kosurkar, U.; Kumar, K. V.J. Heterocyclic Chem.2012,49, 342{348.
  • 35.Hegarty, A. F.; Cashman, M. P.; Scott, F. L.Chem. Commun.1971, 684{685.
  • 36.Dieckmann, W.; Platz, L.Ber. Dtsch Chem. Ges.1906,38, 2989{2995.
  • 37.Eweiss, N. F.; Abdelhamid, A. O.J. Heterocycl. Chem.1980,17, 1713{1717.
Turkish Journal of Chemistry-Cover
  • ISSN: 1300-0527
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Arşiv
Sayıdaki Diğer Makaleler

Kamal M. DAWOOD, Eman A. RAGAB, Korany A. ALI

Enhanced delivery of epirubicin by polyoxometalate-based magnetic nanocarriers:controlled drug loading and pH-sensitive drug release

Nasibeh RAHPEYMA, Ezzat RAFIEE

Serkan Naci KOÇ, Kübra DAYIOĞLU, Hasan ÖZDEMİR

Synthesis of graft copolymer of kappa-carrageenan using microwave energy andstudies of swelling capacity, occulation properties, and preliminary acute toxicity

Tapan Kumar GIRI, Minakshi PRADHAN, Dulal Krishna TRIPATHI

ELİF ANT BURSALI, SERAP SEYHAN BOZKURT, MÜRÜVVET YURDAKOÇ

Ezzat RAFIEE, Nasibeh RAHPEYMA

Polybrominated methoxy- and hydroxynaphthalenes

Osman ÇAKMAK, Kıymet BERKİL AKAR, Tuncay TUNÇ

Impregnation of different ionic liquids onto cationic starch and their comparisonin the extraction of Th(IV)

Mürüvvet YURDAKOÇ, Elif ANT BURSALI, Serap BOZKURT SEYHAN

Heterogeneous Fenton-like degradation of Acid Red 17 using Fe-impregnatednanoporous clinoptilolite: arti cial neural network modeling andphytotoxicological studies

Mehrangiz FATHINIA, Soghra BOZORG, Alireza KHATAEE

Tapan Kumar GIRI, Minakshi PRADHAN, Dulal Krishna TRIPATHI