Enhanced delivery of epirubicin by polyoxometalate-based magnetic nanocarriers:controlled drug loading and pH-sensitive drug release

A series of polyoxometalate-based magnetic nanoparticles were developed as novel carriers for anticancerdrugs. Characterization of the nanoparticles was done by transmission electron microscopy (TEM), scanning electronmicroscopy (SEM), Fourier transform infrared spectroscopy (FTIR), wavelength dispersive X-ray (WDX), and laserparticle size analyzer. Epirubicin (EPI) was selected as a model drug. EPI loading efficiency, EPI loading content, andEPI release pro les were studied. Drug loading was controlled using acid-base titration since H+was released duringthe loading process. Based on these investigations, an efficient EPI delivery system was introduced. It showed highEPI-loading capacity (35.2 wt.%) and high EPI loading efficiency (97.9%). The EPI release in acetate buffer (87.7%)was greater than that in phosphate buffered saline (51.2%). The pH-sensitive release, high EPI loading content, andexcellent EPI loading efficiency are the main bene ts of the presented drug delivery system. The pH-sensitive releaseof EPI may decrease its cytotoxicity. Moreover, the magnetic carrier could be used as a contrast agent in magneticresonance imaging.

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