İsmail KAYAGİL and Şeref DEMİRAYAK

7590

Synthesis of some 2,3,6,8-tetraarylimidazo[1,2-a]pyrazine derivatives by using either reflux or microwave irradiation method, and investigation their anticancer activities

In this study, some 2,3,6,8-tetraarylimidazo[1,2-a]pyrazine derivatives were synthesized by reacting 1-(2-aryl-2-oxoethyl)-2-aryloyl-4,5-diarylimidazoles from 2-aryloyl-4,5-diarylimidazole and 2-bromoacetophenone derivatives with ammonium acetate in acetic acid by using the method that was previously developed and repeatedly tested in our studies. Structural elucidation of the compounds was performed by IR, 1H-NMR, and MASS spectroscopic data and elemental analysis results. Anticancer activities of selected compounds were evaluated and the noticeable activity values were reported.
Anahtar Kelimeler:

Substituted imidazoles, imidazo[1, 2-a]pyrazines, microwave irradiation, anticancer activity

Synthesis of some 2,3,6,8-tetraarylimidazo[1,2-a]pyrazine derivatives by using either reflux or microwave irradiation method, and investigation their anticancer activities

In this study, some 2,3,6,8-tetraarylimidazo[1,2-a]pyrazine derivatives were synthesized by reacting 1-(2-aryl-2-oxoethyl)-2-aryloyl-4,5-diarylimidazoles from 2-aryloyl-4,5-diarylimidazole and 2-bromoacetophenone derivatives with ammonium acetate in acetic acid by using the method that was previously developed and repeatedly tested in our studies. Structural elucidation of the compounds was performed by IR, 1H-NMR, and MASS spectroscopic data and elemental analysis results. Anticancer activities of selected compounds were evaluated and the noticeable activity values were reported.
Keywords:

Substituted imidazoles, imidazo[1, 2-a]pyrazines, microwave irradiation, anticancer activity,

PDF
Turkish Journal of Chemistry-Cover
  • ISSN: 1300-0527
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Arşiv
Sayıdaki Diğer Makaleler

Structural studies of complex compounds of 6,6' -diacetyl-2,2' -bipyridine dioxime with copper(I/II), platinum(II), and palladium(II) metal ions

Erol EROĞLU, Burak ÇOBAN, Abdurrahman ŞENGÜL, Hakan AĞAC

Structural studies of complex compounds of 6,6'-diacetyl-2,2'-bipyridine dioxime with copper(I/II), platinum(II), and palladium(II) metal ions

Abdurrahman ŞENGÜL, Hakan AĞAÇ, Burak ÇOBAN and Erol EROĞLU

A Simple and Rapid Spectrophotometric Determination of Trace Level Simple and rapid spectrophotometric determination of trace level chromium using bis (salicylaldehyde) orthophenylenediamine in nonionic micellar media

Rubina SOOMRO, M. Jamaluddin AHMED and Najma MEMON, Najma MEMON

Azocalixarenes.7: Synthesis and study of the absorption properties of novel mono-azo substituted chromogenic calix[4]arenes

Özlem ÖZEN KARAKUŞ and Hasalettin DELİGÖZ

Simple and rapid spectrophotometric determination of trace level chromium using bis (salicylaldehyde) orthophenylenediamine in nonionic micellar media

M. Jamaluddin AHMED, Najma MEMON, Rubina SOOMRO

Reaction dynamics of Br + HD: quantum wave packet on three potential energy surfaces

Qing SONG, Wei-Long QUAN and Tian-Jun FENG

Effect of CMC and HPC mixture on the photocatalytic activity of Nd-$TiO_2/SiO_2$ film under visible light irradiation

Parviz Aberoomand AZAR, Shahram Moradi DEHAGHI, Susan SAMADI, Mohammad Saber TEHRANI, Mohammad Hadi GIVIANRAD

Synthesis and antiinflammatory activity of novel 2,5-disubstituted thiophene derivatives

Sahar Mohamed Ibrahim BADR

Simultaneous determination of trace Sn(II) and Sn(IV) using differential pulse polarography and application

Ülkü ÜNAL and Güler SOMER

Synthesis and evaluation of the analgesic activity of some new isoxazolo[4,5-d]pyridazin-4(5H)-one derivatives

Oya ÜNSAL TAN, Keriman ÖZADALI, Özgür YEŞİLYURT