H. Ozan GÜLCAN, Serdar ÜNLÜ, Erden BANOĞLU, M. Fethi ŞAHİN

7582

Synthesis of New 4-(5-Chloro-2-oxo-3H-benzoxazol-3-yl)butanamide Derivatives and Their Analgesic and Anti-Inflammatory Properties

In this preliminary screening study for developing potent analgesic and anti-inflammatory compounds, eight new 4-(5-chloro-2-oxo-3H-benzoxazol-3-yl)butanamide derivatives were synthesized and screened for their analgesic and anti-inflammatory activities as well as gastric ulceration potential in tested animals. Their structures were elucidated by their IR, 1H-NMR and elemental analysis. All of the compounds exhibited high analgesic and anti-inflammatory activities. None of the compounds except compound 2g caused gastric lesions or bleeding in tested animals.

Anahtar Kelimeler:

2-Oxo-3H-benzoxazole, butanamide, analgesic, anti-inflammatory, COX-1, COX-2.

Synthesis of New 4-(5-Chloro-2-oxo-3H-benzoxazol-3-yl)butanamide Derivatives and Their Analgesic and Anti-Inflammatory Properties

In this preliminary screening study for developing potent analgesic and anti-inflammatory compounds, eight new 4-(5-chloro-2-oxo-3H-benzoxazol-3-yl)butanamide derivatives were synthesized and screened for their analgesic and anti-inflammatory activities as well as gastric ulceration potential in tested animals. Their structures were elucidated by their IR, 1H-NMR and elemental analysis. All of the compounds exhibited high analgesic and anti-inflammatory activities. None of the compounds except compound 2g caused gastric lesions or bleeding in tested animals.

Keywords:

2-Oxo-3H-benzoxazole, butanamide, analgesic, anti-inflammatory, COX-1, COX-2.,

Turkish Journal of Chemistry-Cover

ISSN: 1300-0527
Yayın Aralığı: 6
Yayıncı: TÜBİTAK

Arşiv

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