Semra UTKU, Mustafa TOPAL, Aylin DÖĞEN

92103

Synthesis, characterization, antibacterial and antifungal evaluation of some new platinum(II) complexes of 2-phenylbenzimidazole ligands

A series of platinum(II) complexes of the type [PtL2Cl2] 1, [PtL2I2] 2, [PtL2(oxalato)] 3, and [PtL2(malonato)] 4 (L= 2-phenylbenzimidazole ligands as ``non-leaving groups'') were synthesized and characterized by their elemental analyses, IR, 1H NMR, and ESI-LC/MS. The in vitro antimicrobial activity of the synthesized compounds has been evaluated by the macrodilution method against gram-positive bacteria, such as Staphylococcus aureus, Bacillus subtilis, and Enterococcus faecalis; gram-negative bacteria, such as Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumonia; and yeast like fungi, such as Candida glabrata and Candida parapsilosis. In general, based on the data obtained in this study, synthesized complexes 1-4 might be taken into consideration as promising antifungal compounds.
Anahtar Kelimeler:

Antibacterial activity, antifungal activity, benzimidazole, carboxylato complexes, platinum(II) complexes.

Synthesis, characterization, antibacterial and antifungal evaluation of some new platinum(II) complexes of 2-phenylbenzimidazole ligands

A series of platinum(II) complexes of the type [PtL2Cl2] 1, [PtL2I2] 2, [PtL2(oxalato)] 3, and [PtL2(malonato)] 4 (L= 2-phenylbenzimidazole ligands as ``non-leaving groups'') were synthesized and characterized by their elemental analyses, IR, 1H NMR, and ESI-LC/MS. The in vitro antimicrobial activity of the synthesized compounds has been evaluated by the macrodilution method against gram-positive bacteria, such as Staphylococcus aureus, Bacillus subtilis, and Enterococcus faecalis; gram-negative bacteria, such as Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumonia; and yeast like fungi, such as Candida glabrata and Candida parapsilosis. In general, based on the data obtained in this study, synthesized complexes 1-4 might be taken into consideration as promising antifungal compounds.
Keywords:

Antibacterial activity, antifungal activity, benzimidazole, carboxylato complexes, platinum(II) complexes.,

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Turkish Journal of Chemistry-Cover
  • ISSN: 1300-0527
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Arşiv
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