Aysel GÜRSOY, Nilgün KARALI

5776

Synthesis, Characterization and Primary Antituberculosis Activity Evaluation of 4-(3-Coumarinyl)-3-benzyl-4-thiazolin-2-one Benzylidenehydrazones

In this study a new series of 4-(3-coumarinyl)-3-benzyl-4-thiazolin- 2-one benzylidenehydrazones 3a-t was synthesized. Structures of the title compounds were elucidated by elemental analyses and spectrometric data (IR, 1H-NMR, 13C-NMR and EIMS). 3a-t were evaluated for antituberculosis activity against Mycobacterium tuberculosis} H37Rv in BACTEC 12B medium using the BACTEC 460 radiometric system.

Anahtar Kelimeler:

Coumarinylthiazolines, synthesis, antituberculosis activity

Synthesis, Characterization and Primary Antituberculosis Activity Evaluation of 4-(3-Coumarinyl)-3-benzyl-4-thiazolin-2-one Benzylidenehydrazones

In this study a new series of 4-(3-coumarinyl)-3-benzyl-4-thiazolin- 2-one benzylidenehydrazones 3a-t was synthesized. Structures of the title compounds were elucidated by elemental analyses and spectrometric data (IR, 1H-NMR, 13C-NMR and EIMS). 3a-t were evaluated for antituberculosis activity against Mycobacterium tuberculosis} H37Rv in BACTEC 12B medium using the BACTEC 460 radiometric system.

Keywords:

Coumarinylthiazolines, synthesis, antituberculosis activity,

Turkish Journal of Chemistry-Cover

ISSN: 1300-0527
Yayın Aralığı: 6
Yayıncı: TÜBİTAK

Arşiv

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Synthesis, Characterization and Primary Antituberculosis Activity Evaluation of 4-(3-Coumarinyl)-3-benzyl-4-thiazolin-2-one Benzylidenehydrazones

Aysel GÜRSOY, Nilgün KARALI