Synthesis and Cytotoxic Activity of Platinum(II) and Platinum(IV) Complexes with 2-Hydroxymethylbenzimidazole or 5(6)-Chloro-2-hydroxymethylbenzimidazole Ligands against MCF-7 and HeLa Cell Lines

Four platinum(II) and 4 platinum(IV) complexes with the structures [PtL2Cl2], [PtL2I2], [PtL2Cl4], and [PtL2Cl2(OH)2] (L = 5(6)-non/orchloro-substituted-2-hydroxymethylbenzimidazole ligands as ``non-leaving groups''), respectively, were synthesized and characterized by their elemental analyses, and IR and 1H-NMR spectra. In vitro cytotoxic activities of the platinum(II) and platinum(IV) complexes were tested against the human MCF-7 (breast cancer) and HeLa (cervix cancer) cell lines using the cell culture method. In general, the platinum(II) complexes were more active than the corresponding platinum(IV) complexes. The complexes, which were found to be less active than cisplatin, exhibited cyctotoxicity comparable to carboplatin on the human MCF-7 and HeLa cell lines.

Synthesis and Cytotoxic Activity of Platinum(II) and Platinum(IV) Complexes with 2-Hydroxymethylbenzimidazole or 5(6)-Chloro-2-hydroxymethylbenzimidazole Ligands against MCF-7 and HeLa Cell Lines

Four platinum(II) and 4 platinum(IV) complexes with the structures [PtL2Cl2], [PtL2I2], [PtL2Cl4], and [PtL2Cl2(OH)2] (L = 5(6)-non/orchloro-substituted-2-hydroxymethylbenzimidazole ligands as ``non-leaving groups''), respectively, were synthesized and characterized by their elemental analyses, and IR and 1H-NMR spectra. In vitro cytotoxic activities of the platinum(II) and platinum(IV) complexes were tested against the human MCF-7 (breast cancer) and HeLa (cervix cancer) cell lines using the cell culture method. In general, the platinum(II) complexes were more active than the corresponding platinum(IV) complexes. The complexes, which were found to be less active than cisplatin, exhibited cyctotoxicity comparable to carboplatin on the human MCF-7 and HeLa cell lines.

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Turkish Journal of Chemistry-Cover
  • ISSN: 1300-0527
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler

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Fragmentation of $Xe^{129}$ in the liquid-gas phase transition region

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Development of a New Set of Additive Parameters for the Estimation of Geometrical Distortion of Cycloalkanes from C-13 NMR Chemical Shifts

Emad A. S. AL-HYALI

Benzimidazolylidene Carbene Ligated Palladium Catalysis of the Heck Reaction in Aqueous Media

İsmail ÖZDEMİR, Yetkin GÖK, Nevin GÜRBÜZ, Bekir ÇETİNKAYA

Fragmentation of Xe129 in the Liquid-Gas Phase Transition Region

Mehmet ERDOĞAN, Nihal BÜYÜKÇİZMECİ, Rıza OĞUL

Synthesis and Cytotoxic Activity of Platinum(II) and Platinum(IV) Complexes with 2-Hydroxymethylbenzimidazole or 5(6)-Chloro-2-hydroxymethylbenzimidazole Ligands against MCF-7 and HeLa Cell Lines

Semra UTKU, Fatma GÜMÜŞ, Sibel GÜR, Aykut ÖZKUL

Selenium and Trace Element Distribution in Astragalus Plants: Developing a Differential Pulse Polarographic Method for Their Determination

Güler SOMER, A. Cengiz ÇALIŞKAN

A New Ursane-type Triterpenoid from Salvia santolinifolia

Zaheer AHMAD, Sajid MEHMOOD, Rehana IFZAL, Abdul MALIK

PVC-Membrane Electrodes Based on 18-Crown-6 and Dibenzo-18-Crown-6 Ethers for Determination of Silver

Mohsen Mousa ZAREH, Magda A. AKL, Ahmd Khlil GOHNEIM And, Mohmed Hussin ABD EL-AZIZ