Tatjana DJAKOVIC SEKULIC, Costel SRBU, Nada PERISIC JANJIC

97110

Quantitative Structure--Retention Study of Some 2,4-dioksotetrahydro- 1,3--thiazole Derivatives Using the Partial Least Squares Method

Thin-layer chromatography on rice starch support and aqueous ammonia--organic modifier (methanol, dioxane, and acetone) mobile phases was used to study the effect on retention of the chromatographic system and the physicochemical properties of twelve 2,4-dioxotetrahydro-1,3-thiazoles. A multivariate approach to the retention behaviour of the investigated compounds with 3 quite different organic solvents was used to explain the interactions between the 1,3-thiazoles and the mobile phases. Partial least-squares (PLS) regression was used to quantify differences between the observed data and recognize the molecular properties with the greatest effect on retention for each modifier. Good correlation was obtained between experimental and calculated retention data.
Anahtar Kelimeler:

2, 4-dioksotetrahydro-1, 3-thiazoles, Quantitative Structure-Retention Relationships (QSRR), Molecular descriptors, Partial Least Squares Regression (PLS)

Quantitative Structure--Retention Study of Some 2,4-dioksotetrahydro- 1,3--thiazole Derivatives Using the Partial Least Squares Method

Thin-layer chromatography on rice starch support and aqueous ammonia--organic modifier (methanol, dioxane, and acetone) mobile phases was used to study the effect on retention of the chromatographic system and the physicochemical properties of twelve 2,4-dioxotetrahydro-1,3-thiazoles. A multivariate approach to the retention behaviour of the investigated compounds with 3 quite different organic solvents was used to explain the interactions between the 1,3-thiazoles and the mobile phases. Partial least-squares (PLS) regression was used to quantify differences between the observed data and recognize the molecular properties with the greatest effect on retention for each modifier. Good correlation was obtained between experimental and calculated retention data.
Keywords:

2, 4-dioksotetrahydro-1, 3-thiazoles, Quantitative Structure-Retention Relationships (QSRR), Molecular descriptors, Partial Least Squares Regression (PLS),

PDF
Turkish Journal of Chemistry-Cover
  • ISSN: 1300-0527
  • Yayın Aralığı: 6
  • Yayıncı: TÜBİTAK
Arşiv
Sayıdaki Diğer Makaleler

Mild and Efficient Iodination of Aromatic Compounds with Trichloroisocyanuric Acid/I2/Wet SiO2 System

Batool AKHLAGHINIA, Marzieh RAHMANI

Quantitative structure-retention study of some 2,4-dioksotetrahydro-1,3-thiazole derivatives using the partial least squares method

Djakovıc Tatjana SEKULIC, Costel SARBU, Perisic Nada JANJIC, Lozanov Zagorka CRVENKOVIC

Synthesis and characterization of tetraoxime ligand, bis-(2E,3E.2'E)-3,3'-(1,2-phenylene-dinitrilo) dibutan-2- one dioxime) and its dinuclear and tetranuclear copper (II) /nickel (II) complexes

Nevin KARABÖCEK, Serdar KARABÖCEK, Pınar EKMEKÇİOĞLU, Aslıgül KÜÇÜKDUMLU

On the structure sensitivity of CO oxidation on alumina supported Pd-Pt bimetallic catalysts

Şinasi ELLİALTIOĞLU, Riad SHALTAF, Sarp KAYA, Deniz UNER, Ebru ERUNAL

Bromination of Tetrachlorobenzobarrelene: Polyhalogenated Benzobicyclics

Mehmet Emin ŞENGÜL, Demet Demirci GÜLTEKİN, Selçuk EŞSİZ, Arif DAŞTAN

Synthesis and Characterization of Tetraoxime Ligand, Bis-[(2E,3E,2´E)-3,3´-(1,2-Phenylene-Dinitrilo)dibutan-2-One Dioxime] and Its Dinuclear and Tetranuclear Copper(II)/Nickel(II) Complexes

Nevin KARABÖCEK, Pınar EKMEKÇİOĞLU

Nitric Oxide Releasing Derivatives of [(2-Chloroethyl)ureido] Benzoic Acid Esters as Potential Antineoplastic Agents

Hülya AKGÜN, Barkın BERK, Dilek Demir EROL

Synthesis and Antimicrobial and Antitumor Activity of Some New [1,2,4] Triazole-5-one Derivatives

Yasemin ÜNVER, Esra DÜĞDÜ, Kemal SANCAK

Silver Ion-Assisted Ring Expansions in Different Solvent Systems

Mesut BOZ, Hafize ÇALIŞKAN, Ömer ZAİM

Mild and efficient iodination of aromatic compounds with trichloroisocyanuric acid /$I_2$ /Wet $SiO_2$ system

Marzieh RAHMANI, Batool AKHLAGHINIA