New Diterpenoids from the Aerial Parts of Salvia pilifera
Three new diterpenoids, piliferol (2a, 20-dihydroxy-12-oxo- abieta-9(11),13-dien-8,20-ether) (1), salvipiliferol (2a, 10b -dihydroxy-12-oxo-norabieta-9(11),13-dien) (2), and piliferalactone (2a ,8-dihydroxy-12-oxo-abieta-9(11),13-dien-20-oic acid-8,20-lactone) (3), together with 7 known compounds, ursolic acid, oleanolic acid, betulinic acid, a -amyrin, lupeol, b -sitosterol, and pectolinarigenin, have been isolated from the aerial parts of an endemic Salvia species, S. pilifera. Their structures were elucidated by spectral (UV, IR, 1D-, and 2D-NMR, and HRMS) methods.
New Diterpenoids from the Aerial Parts of Salvia pilifera
Three new diterpenoids, piliferol (2a, 20-dihydroxy-12-oxo- abieta-9(11),13-dien-8,20-ether) (1), salvipiliferol (2a, 10b -dihydroxy-12-oxo-norabieta-9(11),13-dien) (2), and piliferalactone (2a ,8-dihydroxy-12-oxo-abieta-9(11),13-dien-20-oic acid-8,20-lactone) (3), together with 7 known compounds, ursolic acid, oleanolic acid, betulinic acid, a -amyrin, lupeol, b -sitosterol, and pectolinarigenin, have been isolated from the aerial parts of an endemic Salvia species, S. pilifera. Their structures were elucidated by spectral (UV, IR, 1D-, and 2D-NMR, and HRMS) methods.
___
- H.M. Chang andP.P.H. But, “Pharmacology and Applications of Chinese Materia Medica”, Vol. 1, pp. 255-268, WorldScientiŞc Publication Co., Singapore, 1986.
- J.F. Morton, “Atlas of Medicinal Plants of Middle America: Bahamas to Yucatan”, pp. 780-784, C.C. Thomas Pub. Ltd., SpringŞeld, Illinois, 1981.
- I.C. Hedge, “Salvia ” in Flora of Turkey and the East Aegean Islands, Vol. 7, ed. P.H. Davis, pp. 400-461, University Press, Edinburgh, 1982.
- A. Ulubelen, S. ¨Ozt¨urk andS. I¸sıldatıcı, J. Pharm. Sci. 57, 1037-39 (1968).
- U. Kolak, S¸. Arı, S. Hasan¸cebi, H. Birman andA. Ulubelen, Planta Medica 67, 761-3 (2001).
- G. Top¸cu, Z. T¨urkmen, A. Ulubelen, J.K. Schilling andD.G.I. Kingston, J. Nat. Prod. 67, 118-21 (2004).
- B. Demirci, K.H.C. Ba¸ser, B.Yıldız and Z. Bah¸cecio˘glu, Flavour and Fragrance Journal 18, 116-21 (2003).
- Y.Z. Kocabas andS. Karaman, Pak. J. Bio. Sci. 4, 1221-3 (2001).
- S. Yasar, O. Sagdic and A.N. Kisioglu, J. Food, Agriculture and Environment 3, 39-43 (2005).
- M. Ogura, G.A. Cordell and N.R. Farnsworth, Lloydia 40, 157-68 (1977).
- A. Ikuta andH. Itokawa, Phytochemistry 27, 2813-5 (1988).
- U. Kolak, G. Top¸cu, S. Birteks¨oz, G. ¨Ot¨uk andA. Ulubelen, Turk. J. C hem. 29, 177-86 (2005).
- B. Garcia, J.A. Marco, E. Seoane andA. Tortajada, J. Nat. Prod. 44, 111-3 (1981).
- M.D. DellaGreca, P. Monaco andL. Previtera, J. Nat. Prod. 53,1430-5 (1990).
- R. Mues, B.N. Timmermann, N. Ohno andT.J. Mabry, Phytochemistry 18, 1379-83 (1979).
- M.C. Chamy, M. Piovano, J.A. Garbarino andA. Chaparro, Phytochemistry 40, 1209-12 (1995).
- B. Esquivel, M. Flores, S. Hernandez-Ortega, R.A. Toscano and T.P. Ramamoorthy, Phytochemistry 39, 43 (1995).
- A. Ulubelen, G. Top¸cu, S. Chen, P. Cai andJ.K. Snyder, J. Org. Chem. 56, 7354-6 (1991).
- A. Ulubelen andG. Top¸cu, “Chemical and Biological Investigations of Salvia Species Growing in Turkey” in Studies in Natural Products Chemistry, Vol. 20, Structure and Chemistry (Part F), ed. Atta-ur- Rahman, pp. 659-718, Elsevier, Amsterdam, 1998.