Nepetalactones and other constituents of $Nepeta nuda$ ssp. $albiflora$

Nepetalactones and other constituents of $Nepeta nuda$ ssp. $albiflora$

The hexane extract of Nepeta nuda ssp. albiflora led to the isolation of six known monoterpene nepetalactones, 4a$alpha$,7$alpha$,7a$alpha$-nepetalactone (1), 4a$alpha$,7$alpha$,7$abeta$-nepetalactone (2), 4a$beta$,7$alpha$,7a$beta$-nepetalactone (3), 4a$beta$,7$alpha$,7a$alpha$-nepetalactone (4), 4a$alpha$,7$beta$,7a$beta$-nepetalactone (5), 3$alpha$-hydroxy-4a$alpha$,7$alpha$,7a$alpha$-dihydron-epetalactone (=nepetalic acid) (6) and a dimeric 5,9-dehydronepetalactone (7) along with two known steroids b-sitosterol and sitosterol 3-one and a triterpene betulinic acid. The acetone extract of the same plant afforded compound 7 in a higher yield in addition to compounds 2 and 6, and sesquiterpene caryophyllene oxide, the iridoid glucoside 1,5,9-epideoxyloganic acid, the triterpenoids oleanolic, ursolic and betulinic acids, and sitosterol 3$beta$-glucoside.

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