Facile synthesis of heteroaryl substituted -lactams from nitrovinyl arenes

Aliphatic nitroalkanes with different functional groups were synthesized from the Michael addition reactions of active methylene compounds 2 and nitrovinyl arenes 1 in high yields. The synthesized Michael adducts were subjected to intramolecular cyclization to give heteroaryl substituted -lactams in good to high yields under mild reaction conditions.

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