Ahmed M. FOUDA, Yossry A. AMMAR, Abdallah G. AL SEHEMI, Mohamed S. A. El GABY, Hamdy Kh. THABET, Samir BONDOCK

177

Facile and convenient synthesis of pyrimidine, 4H-3,1-benzoxazin-4-one, pyrazolo[5,1-b]quinazoline, pyrido[1,2-a]quinazoline, and chromeno[3',4 ' :4,5]pyrido[1,2-a]quinazoline derivatives

Facile and convenient synthesis of pyrimidine, 4H-3,1-benzoxazin-4-one, pyrazolo[5,1-b]quinazoline, pyrido[1,2-a]quinazoline, and chromeno[3',4 ' :4,5]pyrido[1,2-a]quinazoline derivatives

A convenient synthesis of a series of pyrimidine, 4H-3,1-benzoxazin-4-one, pyrazolo[5,1- b]quinazoline, pyrido[1,2-a]quinazoline, and chromeno[3',4 ':4,5]pyrido[1,2-a]quinazoline derivatives, via the reactions of versatile and readily accessible methyl 2-(2-cyanoacetamido)benzoate (1) with the appropriate reagents, is described here.
PDF

___

  • 1. Xue, S.; McKenna, J.; Shieh, W. C.; Repi, O. C. J. Org. Chem. 2004, 69, 6474-6477.
  • 2. Honkanen, E.; Pippuri, A.; Kairisalo, P.; Nore, P.; Karppanen, H.; Paakkari, I. J. Med. Chem. 1983, 26, 1433-1438.
  • 3. Zhou, Y.; Murphy, D. E.; Sun, Z.; Gregor, V. E. Tetrahedron Lett. 2004, 45, 8049-8051.
  • 4. Panneerselvam, P.; Pradeep, C. R. V.; Sridhar, S. K. Indian J. Pharm. Sci. 2003, 65, 268-273.
  • 5. Refaie, F.M.; Esmat, A. Y.;Gawad, S. M. A.; Ibrahim, A.M.; Mohamed, M. A. Lipids Health Dis. 2005, 4, 22-32.
  • 6. Habib, N. S.; Ismail, K. A.; El-Tombary, A. A.; Abdel-Aziem, T. Pharmazie 2000, 55, 495-502.
  • 7. Jessy, E. M.; Sambanthan, A. T.; Alex, J.; Sridevi, C. H.; Srinivasan, K. K. Indian J. Pharm. Sci. 2007, 69, 476-478.
  • 8. Alagarsamy, V.; Solomon, V. R.; Dhanabal, K. Bioorgan. Med. Chem. 2007, 15, 235-241.
  • 9. Georgey, H. H.; Abdel-Gawad, N.; Abbas, S. Molecules 2008, 13, 2557-2569.
  • 10. Guan, L. P.; Jin, Q. H.; Tian, G. R.; Chai, K. Y.; Quan, Z. S. J. Pharm. Sci. 2007, 10, 254-262.
  • 11. Abbas, S. E. S. Bull. Fac. Pharm. Cairo Uni. 2007, 45, 119-129.
  • 12. Malawska, B. Curr. Top. Med. Chem. 2005, 5, 69-85.
  • 13. Archana, K.; Srivastava, V. K.; Kumar, A. Bioorgan. Med. Chem. 2004, 12, 1257-1264.
  • 14. Li, J.; Meng, Y.; Liu, Y.; Feng, Z.; Chen, X. Invest. New Drugs 2010, 28, 132-138.
  • 15. Chandrika, P. M.; Yakaiah, T.; Rao, A. R. R.; Narsaiah, B.; Reddy, N. C.; Sridhar, V.; Rao, J. V. Eur. J. Med. Chem. 2008, 43, 846-852.
  • 16. Foote, K. M.; Mortlock, A. A.; Heron, N. M.; Jung, F. H.; Hill, G. B.; Pasquet, G.; Brady, M. C.; Green, S.; Heaton, S. P.; Kearney, S.; Keen, N. J.; Odedra, R.; Wedge, S. R.; Wilkinson, R. W. Bioorg. Med. Chem. Lett. 2008, 18, 1904-1909.
  • 17. Cao, S. L.; Feng, Y. P.; Jiang, Y. Y.; Liu, S. Y.; Ding, G.Y.; Li, R. T. Bioorg. Med. Chem. Lett. 2005, 15, 1915-1917.
  • 18. Al-Omary, F. A. M.; Abou-Zeid, L. A.; Nagi, M. N.; Habib, E. E.; Abdel-Aziz, A. A. M.; El-Azab, A. S.; Abdel- Hamide, S. G.; Al-Omar, M. A.; Al-Obaid, A. M.; El-Subbagh, H. I. Bioorgan. Med. Chem. 2010, 18, 2849-2863.
  • 19. Bondock, S.; Rabie, R.; Etman, H. A.; Fadda, A. A. Eur. J. Med. Chem. 2008, 43, 2122-2129.
  • 20. Bondock, S.; Fadaly, W.; Metwally, M. A. Eur. J. Med. Chem. 2009, 44, 4813-4818.
  • 21. Fadda, A. A.; Bondock, S.; Rabie, R.; Etman, H. A. Turkish J. Chem. 2008, 32, 259-286.
  • 22. Bondock, S.; Fadaly, W.; Metwally, M. A. Eur. J. Med. Chem. 2010, 45, 3692-3701.
  • 23. Ammar, Y. A.; Aly, M. M.; Mohamed, Y. A.; Al-Sehemi, A.G.; Salem, M.A.; El-Gaby, M. S. A. Phosphorus, Sulfur, Silicon 2008, 183, 1710-1721.
  • 24. Ammar, Y. A.; Thabet, H. Kh.; Aly, M. M.; Mohamed, Y. A.; Ismail, M. A.; Salem, M. A. Phosphorus, Sulfur, Silicon 2010, 185, 743-753.
  • 25. Helal, M. H.; El-Hag Ali, G. A. M.; Ali, A. A.; Ammar, Y. A. J. Chem. Res. 2010, 465-469.
  • 26. El-Hag Ali, G. A. M.; Helal, M. H.; Mohamed, Y. A.; Ali, A. A.; Ammar, Y. A. J. Chem. Res. 2010, 459-464.
  • 27. Ukrainets, I. V.; Taran, S. G.; Bezugly, P. A.; Kovalenko, S. N.; Turov, A. V.; Marusenko, N. A. Khim. Geterotsikl. Soedin. 1993, 1223-1226.
  • 28. Kumar, H.; Chandhary, R. P. J. Chem. Pharm. Res. 2010, 2, 667-672.
  • 29. Pal, R.; Handa, R. N.; Pujari, H. K. Indian J. Chem. Soc. 1992, 31B, 771-777.
  • 30. Mladenovi´c, M.; Vukovi´c, N.; Sukdolak, S.; Soluji´c, S. Molecules 2010, 15, 4294-4308.
  • 31. Mladenovi´c, M.; Vukovi´c, N.; Niciforovi´c, N.; Sukdolak, S.; Soluji´c, S. Molecules 2009, 14, 1495-1512.
  • 32. Nawrot, M. J.; Nawrot E.; Graczyk, J. Eur. J. Med. Chem. 2006, 41, 1301-1308
  • 33. Nandgaonkar, R. G.; Ingke, V. N. Asian J. Chem. 2005, 17, 2016-2023
  • 34. Bylov, I. E.; Vasylyev, M. V.; Bilokin, Y. V. Eur. J. Med. Chem. 1999, 34, 997-1001.
Turkish Journal of Chemistry-Cover
  • ISSN: 1300-0527
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK
Arşiv
Sayıdaki Diğer Makaleler

Amphiphilic and chiral unsymmetrical perylene dye for solid-state dye-sensitized solar cells

Hurmus REFIKER, Hüriye İCİL

Chemistry of 2-aminothiophene-3-carboxamide and related compounds

Moustafa A. GOUDA, Moged A. BERGHOT, Ghada E. ABD EL-GHANI

Simultaneous determination of copper and cadmium in environmental water and tea samples by adsorptive stripping voltammetry

Mohammad Bagher GHOLIVAND, Alireza POURHOSSEIN

The sorption of cadmium(II) ions on mercerized rice husk and activated carbon

Mas Rosemal Hakim MAS HARIS, Nor Aimi ABDUL WAHAB, Chong Wan RENG

Synthesis and antimicrobial activity of novel 2-(pyridin-2-yl)thieno[2,3-d]pyrimidin-4 (3H)-ones

Nitin G. HASWANI, Sanjaykumar B. BARI

Arsenic and antimony determination in refined and unrefined table salts by means of hydride generation atomic absorption spectrometry–comparison of sample decomposition and determination methods

Nur AKSUNER, Vedia Nüket TİRTOM, Emür HENDEN

Determination of Ni(II) with picolinaldehyde-4-phenyl-3-thiosemicarbazone used as a chromogenic reagent in a nonionic micellar system

Aamna BALOUCH, Muhammad Iqbal BHANGER, Farah Naz TALPUR

Facile and convenient synthesis of pyrimidine, 4H-3,1-benzoxazin-4-one, pyrazolo[5,1-b]quinazoline, pyrido[1,2-a]quinazoline, and chromeno[3' ,4' :4,5]pyrido[1,2-a]quinazoline derivatives

Yossry A. AMMAR, Samir BONDOCK, Abdallah G. AL-SEHEMI

Power of inhibition activity screening and 3D molecular modeling approaches in HDAC 8 inhibitor design

Gamze BORA TATAR, Tenzile Deniz TOKLUMAN, Kemal YELEKÇİ

Arsenic and antimony determination in refined and unrefined table salts by means of hydride generation atomic absorption spectrometry--comparison of sample decomposition and determination methods

Nur AKSUNER, Vedia Nüket TİRTOM, Emür HENDEN