Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery

Öz In this study, boric acid (BA) is employed as a crosslinking agent to improve the characteristics of two commonly used polymeric films, ethyl cellulose (EC) and polyvinyl alcohol (PVA), for topical drug delivery applications. The developed films are characterized by FIT R spectroscopy and SEM analysis. The results show that the surfaces of the prepared films are even and transparent, except for the BA-modified EC sample. The initial cumulative release for erythromycin (EM) is found to be 0.30 and 0.36 mg/mL for EC and PVA films, which drops to 0.25 and 0.20 mg/mL after BA crosslinking, respectively, after 1 h at 25 degrees C. Further, the developed formulations are stable for 75 days. Also, the antibacterial activity of the developed formulations is investigated against S. aureus (ATCC (R) 25923 (TM) and ATCC (R) 29213 (TM)). The obtained data confirm that the application of BA as the crosslinking agent extends the release of EM from EC and PVA polymeric films. The findings of this study suggest that BA-crosslinked EC and PVA films are promising carriers for controlled topical drug delivery applications.

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Kaynak Göster

Bibtex @araştırma makalesi { tbtkchem945166, journal = {Turkish Journal of Chemistry}, issn = {1300-0527}, eissn = {1303-6130}, address = {}, publisher = {TÜBİTAK}, year = {2020}, volume = {44}, pages = {1723 - 1732}, doi = {}, title = {Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery}, key = {cite}, author = {Aliasgharlou, Nasrin and Asghari Sana, Farzin and Khoshbakht, Saba and Zolfaghari, Pezhman and Charkhian, Hamed} }
APA Aliasgharlou, N , Asghari Sana, F , Khoshbakht, S , Zolfaghari, P , Charkhian, H . (2020). Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery . Turkish Journal of Chemistry , 44 (6) , 1723-1732 .
MLA Aliasgharlou, N , Asghari Sana, F , Khoshbakht, S , Zolfaghari, P , Charkhian, H . "Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery" . Turkish Journal of Chemistry 44 (2020 ): 1723-1732 <
Chicago Aliasgharlou, N , Asghari Sana, F , Khoshbakht, S , Zolfaghari, P , Charkhian, H . "Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery". Turkish Journal of Chemistry 44 (2020 ): 1723-1732
RIS TY - JOUR T1 - Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery AU - Nasrin Aliasgharlou , Farzin Asghari Sana , Saba Khoshbakht , Pezhman Zolfaghari , Hamed Charkhian Y1 - 2020 PY - 2020 N1 - DO - T2 - Turkish Journal of Chemistry JF - Journal JO - JOR SP - 1723 EP - 1732 VL - 44 IS - 6 SN - 1300-0527-1303-6130 M3 - UR - Y2 - 2020 ER -
EndNote %0 Turkish Journal of Chemistry Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery %A Nasrin Aliasgharlou , Farzin Asghari Sana , Saba Khoshbakht , Pezhman Zolfaghari , Hamed Charkhian %T Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery %D 2020 %J Turkish Journal of Chemistry %P 1300-0527-1303-6130 %V 44 %N 6 %R %U
ISNAD Aliasgharlou, Nasrin , Asghari Sana, Farzin , Khoshbakht, Saba , Zolfaghari, Pezhman , Charkhian, Hamed . "Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery". Turkish Journal of Chemistry 44 / 6 (Aralık 2020): 1723-1732 .
AMA Aliasgharlou N , Asghari Sana F , Khoshbakht S , Zolfaghari P , Charkhian H . Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery. Turk J Chem. 2020; 44(6): 1723-1732.
Vancouver Aliasgharlou N , Asghari Sana F , Khoshbakht S , Zolfaghari P , Charkhian H . Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery. Turkish Journal of Chemistry. 2020; 44(6): 1723-1732.
IEEE N. Aliasgharlou , F. Asghari Sana , S. Khoshbakht , P. Zolfaghari ve H. Charkhian , "Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery", Turkish Journal of Chemistry, c. 44, sayı. 6, ss. 1723-1732, Ara. 2020
  • ISSN: 1300-0527
  • Yayın Aralığı: Yılda 6 Sayı
  • Yayıncı: TÜBİTAK

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