Fabrication and characterization of boric acid-crosslinked ethyl cellulose and polyvinyl alcohol films as potential drug release systems for topical drug delivery
In this study, boric acid (BA) is employed as a crosslinking agent to improve the characteristics of two commonly used polymeric films, ethyl cellulose (EC) and polyvinyl alcohol (PVA), for topical drug delivery applications. The developed films are characterized by FIT R spectroscopy and SEM analysis. The results show that the surfaces of the prepared films are even and transparent, except for the BA-modified EC sample. The initial cumulative release for erythromycin (EM) is found to be 0.30 and 0.36 mg/mL for EC and PVA films, which drops to 0.25 and 0.20 mg/mL after BA crosslinking, respectively, after 1 h at 25 degrees C. Further, the developed formulations are stable for 75 days. Also, the antibacterial activity of the developed formulations is investigated against S. aureus (ATCC (R) 25923 (TM) and ATCC (R) 29213 (TM)). The obtained data confirm that the application of BA as the crosslinking agent extends the release of EM from EC and PVA polymeric films. The findings of this study suggest that BA-crosslinked EC and PVA films are promising carriers for controlled topical drug delivery applications.
Keywords:
Drug delivery system polymeric film, polyvinyl alcohol, ethyl cellulose, boric acid, erythromycin,
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- ISSN: 1300-0527
- Yayın Aralığı: Yılda 6 Sayı
- Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler
Mehtap TUGRAK, Halise Inci GUL, Baris ANİL, Ilhami GULCİN
Pezhman ZOLFAGHARI, Nasrin ALIASGHARLOU, Saba KHOSHBAKHT, Farzin ASGHARI SANA, Hamed CHARKHIAN
Hayriye Eda SATANA KARA, Burak DEMİRHAN, Buket ER DEMİRHAN
Ozlem AKGUL, Mumin Alper ERDOGAN, Dervis BİRİM, Cagla KAYABASİ, Cumhur GUNDUZ, Guliz ARMAGAN
Senem GUNER, Yavuz YAGİZ, Zeynal TOPALCENGİZ, Hordur G. KRİSTİNSSON, George BAKER, Paul SARNOSKİ, Bruce A. WELT, Amarat SİMONNE, Maurice R. MARSHALL
Mahesh GAİDHANE, Ajay GHATOLE, Kushal LANJEWAR, Kishor HATZADE
Shaista PARVEEN, Saima KALSOOM, Rifhat BİBİ, Ambreen ASGHAR, Abdul HAMEED, Waqar AHMED, Abbas HASSAN
Emre GUZEL, Fatih SONMEZ, Sultan ERKAN, Kubra CİKRİKCİ, Adem ERGUN, Nahit GENCER, Oktay ARSLAN, Makbule B. KOCAK