Cihangir TANYELİ, Volkan GÜLBEYAZ, Hülya AKGÜN, Ayhan S. DEMİR

12798

Enantioselective synthesis of 4-hydroxy-3-(3-oxo-1-phenly butyl) 2H-1-benzopyran-2-one (warfarin)

Enantioselective synthesis of 4-hydroxy-3-(3-oxo-1-phenly butyl) 2H-1-benzopyran-2-one (warfarin)

Oral anticoagulant Warfarin (4-hydroxy-3-(3-oxo-1-phenyl butyl)-2H-1- benzopyran-2-one) is synthesized in optically active form starting from 4- hydroxycoumarin via formation of optically active enamines followed by Michael addition reaction with benzyliden acetone at low temperature. Different amines gave 17-68% ee and the chemical yield was 22-71%, depending on the reaction conditions and the structure of chiral amines.

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Turkish Journal of Chemistry-Cover

ISSN: 1300-0527
Yayın Aralığı: 6
Yayıncı: TÜBİTAK

Arşiv

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Enantioselective synthesis of 4-hydroxy-3-(3-oxo-1-phenly butyl) 2H-1-benzopyran-2-one (warfarin)

Cihangir TANYELİ, Volkan GÜLBEYAZ, Hülya AKGÜN, Ayhan S. DEMİR