Development of a nanoscale-based optical chemical sensor for the detection of NO radical
Nitric oxide is one of the most important biochemical parameters in
biological processes; it is also known as carcinogenic. There is need for
the design of stable and durable solid phase nitric oxide sensors. In this
study, we immobilized the nitric oxide sensitive molecules pyrene,
tris(2,2'-bipyrdyl)dichlororuthenium(II) hexahydrate
(Ru(bipy)2+3)32+)_{3}^{2+}), and magnesium phthalocyanine (Mg-Pc) for the first
time in polymeric or glassy matrices. We applied silver nanoparticles and
ionic liquids in the fabrication process of polymeric electrospun fibers and
thin films. We compared their NO sensitivity in micelle solutions that mimic
the cell medium by both steady state and lifetime-based fluorescence
measurements. Among the tested dyes, the pyrene exhibited the highest
response for radicalic NO. The Mg-Pc dye followed pyrene in terms of
sensitivity and exhibited increasing fluorescence intensity and
lifetime-based response. Lifetime-based response is advantageous and
selective as it is not affected by source variations, photo-bleaching, or
leaching effects. Another advantage of Mg-Pc dye is that it is not poisonous
for organic systems. Presence of the ionic liquid enhanced the sensor
response in all of the test moieties. The obtained limit of detection values
for pyrene, Ru(bipy)2+332+_{3}^{2+} and Mg-Pc dyes were 0.15 μμ\mu M, 1.54
μμ\mu M, and 0.78 μμ\mu M, respectively.
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