Boric acid as an efficient and green catalyst for the synthesis of 2-amino-4,6-diarylnicotinonitrile under microwave irradiation in solvent-free conditions

Microwave irradiation has been used to improve the one-pot synthesis of substituted 2-amino-4,6-diarylnicotinonitrile in the presence of boric acid as an efficient and green catalyst under solvent-free conditions within 48–60 s. Allthe analogs that have not been reported previously were characterized by their melting points, IR, 1 H NMR, and 13 CNMR spectra. One of the structures was verified by the analysis of a single crystal. The reported synthetic procedureprovided remarkable advantages such as short reaction times, excellent yield, facile workup, and the use of a greencatalyst.

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