Bisabolane Type Sesquiterpenes from a Marine Didiscus Sponge
Two bisabolane type sesquiterpene phenols, (+)-curcuphenol (1) and (+)-curcudiol (2), were isolated from a Philippine marine sponge, Didiscus sp., in addition to b -sitosterol (3) and phenethylamine (4). The structures of the metabolites were established on the basis of spectral evidence (1D- and 2D NMR, [a]D, EIMS). (+)-Curcuphenol (1) showed cytotoxicity, which is indicative of a p53 independent mechanism.
Anahtar Kelimeler:
Marine sponge, Didiscus, (+)-curcuphenol, (+)-curcudiol, b -sitosterol, phenethylamine, HCT-116
Bisabolane Type Sesquiterpenes from a Marine Didiscus Sponge
Two bisabolane type sesquiterpene phenols, (+)-curcuphenol (1) and (+)-curcudiol (2), were isolated from a Philippine marine sponge, Didiscus sp., in addition to b -sitosterol (3) and phenethylamine (4). The structures of the metabolites were established on the basis of spectral evidence (1D- and 2D NMR, [a]D, EIMS). (+)-Curcuphenol (1) showed cytotoxicity, which is indicative of a p53 independent mechanism.
Keywords:
Marine sponge, Didiscus, (+)-curcuphenol, (+)-curcudiol, b -sitosterol, phenethylamine, HCT-116,
- ISSN: 1300-0527
- Yayın Aralığı: Yılda 6 Sayı
- Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler
Characterization of Polyphenol Oxidase from Jerusalem Artichoke (Helianthus tuberosus)
Bisabolane Type Sesquiterpenes from a Marine Didiscus Sponge
Khadija SHAHID, Saqib ALI, Saira SHAHZADI
Synthesis, Characterization and Electrical Conductivity of Poly(p-phenylene vinylene)
Ali ÇIRPAN, Zuhal KÜÇÜKYAVUZ, Savaş KÜÇÜKYAVUZ
Mustafa SOYLAK, Aslıhan Uzun KARATEPE