From the roots of Verbascum lasianthum Boiss. ex Bentham 4 catalpol derivatives, 6-O-(a-L-rhamnopyranosyl)-catalpol (1), verbascoside A [= 6-O-(4''-O-trans-p-methoxycinnamoyl)-a -L-rhamnopy- ranosylcatalpol] (2), pulverulentoside I [= 6-O-(3''-O-acetyl-2''-O-trans-p-methoxycinnamoyl)-a -L-rham-nopyranosylcatalpol] (3), and buddlejoside A5 [= 6-O-(2''-O-acetyl-3''-O-trans-p-methoxycinnamoyl)-a -L-rhamnopyranosylcatalpol] (4), as well as aucubin (5) and an aucubin derivative, unduloside III [= 6-O-(3''-O-trans-p-methoxycinnamoyl)- a-L-rhamnopyranosylaucubin] (6), were isolated and characterized. The structure elucidation of the compounds was established on the basis of spectroscopic evidence. Buddlejoside A5 (4) was found for the first time in the genus Verbascum.

From the roots of Verbascum lasianthum Boiss. ex Bentham 4 catalpol derivatives, 6-O-(a-L-rhamnopyranosyl)-catalpol (1), verbascoside A [= 6-O-(4''-O-trans-p-methoxycinnamoyl)-a -L-rhamnopy- ranosylcatalpol] (2), pulverulentoside I [= 6-O-(3''-O-acetyl-2''-O-trans-p-methoxycinnamoyl)-a -L-rham-nopyranosylcatalpol] (3), and buddlejoside A5 [= 6-O-(2''-O-acetyl-3''-O-trans-p-methoxycinnamoyl)-a -L-rhamnopyranosylcatalpol] (4), as well as aucubin (5) and an aucubin derivative, unduloside III [= 6-O-(3''-O-trans-p-methoxycinnamoyl)- a-L-rhamnopyranosylaucubin] (6), were isolated and characterized. The structure elucidation of the compounds was established on the basis of spectroscopic evidence. Buddlejoside A5 (4) was found for the first time in the genus Verbascum.