Jürgen KRAUSS, Franz BRACHER and Doris UNTERREITMEIER

10786

A New Approach Towards (\pm)-4-Ipomeanol and Its 2-Furyl Regioisomer

The cytotoxic furan derivative (\pm)-4-ipomeanol (1) and its regioisomer (8) were prepared in a new and efficient way starting from commercially available furan derivatives. In both cases the key step was a regioselective solvolysis of the terminal double bond with trifluoroacetic anhydride and boron trifluoride. The resulting compounds were tested in an agar diffusion assay against several bacteria and fungi, but did not show significant activity.

A New Approach Towards (\pm)-4-Ipomeanol and Its 2-Furyl Regioisomer

The cytotoxic furan derivative (\pm)-4-ipomeanol (1) and its regioisomer (8) were prepared in a new and efficient way starting from commercially available furan derivatives. In both cases the key step was a regioselective solvolysis of the terminal double bond with trifluoroacetic anhydride and boron trifluoride. The resulting compounds were tested in an agar diffusion assay against several bacteria and fungi, but did not show significant activity.

Keywords:

(\pm)-4-ipomeanol solvolysis, antimicrobial activity,

Turkish Journal of Chemistry-Cover

ISSN: 1300-0527
Yayın Aralığı: 6
Yayıncı: TÜBİTAK

Arşiv

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A New Approach Towards (\pm)-4-Ipomeanol and Its 2-Furyl Regioisomer

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