A new approach to the ring opening reactions of 2,7,7-trimethyl-3,3-dibromotricyclo[4.1.1.$0^{2,4}$] octane
A new approach to the ring opening reactions of 2,7,7-trimethyl-3,3-dibromotricyclo[4.1.1.$0^{2,4}$] octane
The reaction of $alpha$−pinene and dibromocarbene produced a fairly unstable product, 2,7,7-trimethyl-3,3-dibromotricyclo[4.1.1.$0^{2,4}$]octane, from which 3-bromo-7,7-dimethyl-2-methylenebicyclo[4,1,1]oct-3-ene and 3-bromo-2,7,7-trimethylbicyclo [4,1,1]octa-2,4-diene were obtained in chloroform at room temperature and in various other media and conditions. Two new compounds, 3-bromo-2,7,7-trimethylbicyclo [4.1.1]oct-3-en-2-ol and 2-(4-bromo-5-methylcyclohepta-3,5-dien-1-yl) propan-2-ol, were observed in aqueous acetone in addition to the previous two. The stability and formation mechanism of the formed products are discussed.
___
- 1.E.V. Dehmlow, In Houben-Weyl Methoden der Organischen Chemie; M. Regitz, Ed.; Georg ThiemeVerlag: Stuttgart, Vol. E19, Part 2, pp 1467-1505, 1521-1600, 1608-1622 and 1625-1627, Germany, 1989.
- 2.A. Jonczyk and M. Fedorynski, M. In Houben-Weyl Methods of Organic Chemistry; A. De Meijere, A.,Ed., Georg Thieme Verlag: Vol. E17a, pp 589-734, Stuttgart, Germany, 1997.
- 3.R.R Kostikov, A.P. Molchanov and H. Hopf, Top. Curr. Chem. 155, 41, (1990).
- 4.M.G. Banwell and M.E. Reum, Advances in Strain in Organic Chemistry; Vol. 1, p 19. JAI Press: London,1991.
- 5.M. Fedorynski, Chem Rev. 103, 1099-1132 (2003).
- 6.K.B. Wiberg, In The Chemistry of Functional Groups, The Chemistry of the Cyclopropyl Group,Z. Rappoport, Ed.; Wiley: New York, p 1. 1987.
- 7.D. Cremer, E. Kraka and K.J. Szabo, K. In The Chemistry of Functional Groups, The Chemistry ofthe Cyclopropyl Group, Vol. 2, Z. Rappoport, Ed.; p 43, Wiley: Chichester, U.K., 1995.
- 8.8. L.A. Wessjohann, A. Ludger, A. Muhlbauer and U. Sinks, Acta Chem. Scan. 51, 1112-1115 (1997).
- 9.9. M.G. Banwell and C.J. Cowdenle, Austr. J. Chem. 47, 2235-54 (1994).
- 10.10. D.G. Lindsay and C. B. Reese, Tetrahedron 21, 1673-80, (1965).
- 11.D. Wege, J. Org. Chem. 55, 1667-1670, (1990).
- 12.K. Kitahonoki, Y. Takano, A. Matsuura and K. Kotera, Tetrahedron 25, 335-353 (1969).
- 13.F. Tümer, Y. Taskesenligil and M. Balci, J. Org. Chem. 66, 3806-3810, (2001).
- 14.F. Algı, T. Hökelek and M. Balcı, J. Chem. Res. (S), 658-660, (2004).
- 15.J. Hatem and B. Waegell, Tetrahedron Lett. 23, 2069-2072 (1971).
- 16.J. Graefe, Q.T. Lam and M. Muehlstaedt, Z. Chem. 11, 252-3, (1971).
- 17.J. Hatem and B. Waegell, Tetrahedron Lett. 23, 2019-2022 and 2023-2026, (1973).
- 18.J. Hatem and B. Waegell, Tetrahedron, 46, 2789-2806 (1990).
- 19.For isolation and further reactions of 11 see: M.S. Baird; P. Mark, H. J. Sadler, J.P. Zahra and B. Waegell, J.Chem. Soc. Chem. Commun. 452-453 (1979).
- 20.A. Azizoglu, R. Ozen, T. Hokelek and M. Balci, J. Org. Chem. 69, 1202-1206, (2004).