A Mild Method for the Cleavage of Ketals Using IBX
Investigation on the total synthesis of batrachotoxin 1 revealed that the cyclic ketals could be cleaved to ketone with IBX in DMSO at 70-81 °C under very mild conditions. A variety of functional groups showed no interference under these conditions except vinyl bromides, which, in fact, inhibits the single electron transfer to IBX.
Anahtar Kelimeler:
Deprotection, ketal, IBX, ketone, single electron transfer, batrachotoxin.
A Mild Method for the Cleavage of Ketals Using IBX
Investigation on the total synthesis of batrachotoxin 1 revealed that the cyclic ketals could be cleaved to ketone with IBX in DMSO at 70-81 °C under very mild conditions. A variety of functional groups showed no interference under these conditions except vinyl bromides, which, in fact, inhibits the single electron transfer to IBX.
Keywords:
Deprotection, ketal, IBX, ketone, single electron transfer, batrachotoxin.,
- ISSN: 1300-0527
- Yayın Aralığı: Yılda 6 Sayı
- Yayıncı: TÜBİTAK
Sayıdaki Diğer Makaleler
Zekerya DURSUN, Levent PELİT, İsao TANIGUCHI
Investigation of Biodiesel Production from Canola Oil Using Amberlyst-26 as a Catalyst
Oğuzhan İLGEN, Ayşe Nilgün AKIN, Nezahat BOZ
Sevnur KESKİN, Meral AYDIN, Igor KHUDYAKOV, Nergis ARSU
Hamid Reza SHATERIAN, Asghar Hosseinian And Majid GHASHANG
Water-gas shift reaction over bimetallic Pt-Ni/ $Al_2O_3$ catalysts
Ahmet Erhan AKSOYLU, Burcu selen ÇAĞLAYAN
Abdulkadir SIRIT and Mustafa YILMAZ
Vijay TAILE, Kishor HATZADE, Pravin Gaidhane And Vishwas INGLE
Development of Alumina Supported Alkaline Catalysts Used for Biodiesel Production
Oğuzhan İLGEN, Ayşe Nilgün AKIN
Water-Gas Shift Reaction over Bimetallic Pt-Ni/Al2O3 Catalysts