Two new Achillea species, Achillea adenii Aytaç & M.Ekici and Achillea baltai H.Duman & Aytaç sp. nov. of sect. Santolinoidea DC. (Asteraceae), are described and illustrated as new species. A. adenii grows at Babadağ in Muğla Province (southwestern Anatolia), while A. baltai grows at Aladağlar in Niğde Province. Diagnostic morphological characters, which are useful in discriminating the two new species from their close relatives, A. sintenisii Hub.-Mor., A. sipikorensis Hausskn. & Bornm., and A. armenorum Boiss. & Hausskn., are presented. Some notes on the ecology, pollen and seed morphology, conservation status, and distributions of the new species and a key to related species are also given.