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Maternal transfer of photoperiodic information regulates the postnatal reproductive system development of the mongolian gerbil (Merinos unguiculatus)

Özet: Moğolistan gerbillerinde hamilelik süresince fotoperiyodik bilginin anneden yavruya iletilip iletilmediği ve eğer bir ileti varsa bundan pineal bez ve hormonu melatonin'in sorumlu olup olmadığı araştırıldı. Yetişkin dişi gerbiller iki değişik fotoperiyot altında (12L12D, 8L:16D) çiftleştirildi. Hamile gerbillerin bulunduğu herbir fotoperiyotta üç farklı grup [kontrol (yalancı pinealektomi), pinealektomi ve pinealektomi + melatonin enjeksiyonu] oluşturuldu. Pinealektomiler, gerbiller çiftleştirilmeden önce yapıldı ve melatonin injeksiyonları pinealektomili gruba hamileliğin 8. gününden doğuma kadar uygulandı. Her iki fotoperiyotta doğan yavrular aynı gün anneleri ile birlikte ara fotoperiyot olan 10L14D transfer edildiler. Yavruların sütten kesilme sonrası vücut ağırlık artışı ve erkek gerbillerin gonadal gelişimi sekiz hafta süresince her hafta yapılan ölçümlerle kaydedildi. Hamileliklerini 12L12D fotoperiyodunda geçiren kontrol ve pinealetomi + melatonin enjeksiyonlu annelerden doğan gerbiller 10L:14D'ye kısa fotoperiyot cevabı verdiler ve pinealektomili annelerden doğan gerbillere göre daha küçük testislere sahip oldular (P < 0,05). Hamileliklerini 8L fotoperiyodunda geçiren kontrol ve pinealektomi + melatonin enjeksiyonlu annelerden doğan gerbiller 10L:l4D'ye uzun fotoperiyot cevabı verdiler ve pinealektomili annelerden doğan gerbillere göre daha büyük testislere sahip oldular (P < 0,05). Gruplar arasında vücut ağırlığı gelişimi bakımından anlamlı bir farklılık kaydedilmedi (P > 0,05). Bu sonuçlar göstermektedir ki, Moğolistan gerbillerinde fotoperiyodik bilginin iletiminde annelerin hamilelik süresince içinde bulundukları fotoperiyod etkili olmakta, pineal bezi ve hormonu melatonin önemli bir rol oynamaktadırlar.

Moğalistan gerbillerinde (Meriones unguiculatus) fotoperiyodik bilginin maternal transferi postnatal üreme sistemi gelişimini düzenlemektedir.

Abstract: We investigated whether photoperiodic information is transferred from mother to young and whether the pineal gland and its hormone, melatonin, are involved in this transfer in Mongolian gerbils. Adult female gerbils were paired with males and housed in photoperiods of 12L12D or 8L-.16D. Three groups of pregnafit gerbils in each photoperiod were prepared: one group was the sham-operated control, one group consisted of pinealectomized gerbils, and one group consisted of pinealectomized gerbils that were treated with melatonin. Pinealectomy was performed before pairing the animals and melatonin injections were applied to the pinealectomized group from day 8 of gestation until parturition..-On the day of parturition, the mother and young were transferred to an intermediate photoperiod (10L14D). After weaning, body weight gain and gonadal development of the male young were measured every week over 8 weeks. Animals gestated and born to control and pinealectomized + melatonin injected mothers exposed to 12L12D responded to 10L14D as a short day; they had significantly (P < 0.05) smaller testes than animals born to pinealectomized mothers. Animals gestated and born to control mothers exposed to 8L16D responded to 10L14D as a long day; they had significantly (P < 0.05) larger testes than animals born to pinealectomized and pinealectomized + melatonin injected mothers. Body weights of the gerbils did not vary significantly among the groups (P > 0.05). These results are the first evidence that the photoperiod to which the mother is exposed during gestation affects the postnatal gonadal development of the young and the pineal gland and melatonin play an important role in the transmission of photoperiodic information in the Mongolian gerbil.

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