Zeynep Ustaoğlu İYİGÜNDOĞDU, Selami DEMİRCİ, Nurcan BAÇ, Fikrettin ŞAHİN

Development of durable antimicrobial surfaces containing silver- and zinc-ion-exchanged zeolites

The present work involves development of stable antimicrobial materials containing silver- and zinc-ion-exchanged zeolites. Faujasite X and Linde type A zeolites were synthesized, and following ion exchange with Ag+ and Zn++ ions they were found to exhibit antimicrobial effects against bacteria (E. coli, P. aeruginosa, and S. aureus), yeast (C. albicans and C. glabrata), and fungi (A. niger and P. expansum). Zeolites-X and -A containing silver and zinc ions were then mixed with various coating materials, including paints and polypropylene, to develop antimicrobial composites. The long-term antimicrobial characteristics of zeolite-containing composite materials were investigated by inoculating selected microorganisms onto the surface of the materials. The results indicated that the higher the zeolite concentration present in the composite, the more long-term antimicrobial activity was achieved. Silver-ion-exchanged zeolites were more effective against bacterial and candidal species, while zinc zeolites exhibited noticeable antifungal properties. Materials manufactured with metal-ion-exchanged zeolites would prevent microbial growth on surfaces, reducing cross-contamination and infection risk as well as the microbial degradation of products.

Anahtar Kelimeler:

Key words: Silver, zinc, zeolite, antimicrobial, coating, polypropylene, paint

Development of durable antimicrobial surfaces containing silver- and zinc-ion-exchanged zeolites

Keywords:

Key words: Silver, zinc, zeolite, antimicrobial, coating, polypropylene, paint,

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Adams CJ, Araya A, Carr SW, Chapple AP, Graham P, Minihan AR, Osinga TJ (1995). Zeolite map: a new detergent builder. Stud Surf Sci Catal 98: 206–207.
Baldrian P (2010). Effect of heavy metals on saprotrophic soil fungi. In: Sherameti I, Varma A, editors. Soil Heavy Metals, Soil Biology. Berlin, Heidelberg, Germany: Springer-Verlag, pp. 263–278.
Binder S, Levitt AM, Sacks JJ, Hughes JM (1999). Emerging infectious diseases: public health issues for the 21st century. Science 284: 1311–1313.
Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, Scheld M, Spellberg B, Bartlett J (2009). Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clin Infect Dis 48: 1–12.
Casemiro LA, Martins CHG, Pires‐de‐Souza FdC, Panzeri H (2008). Antimicrobial and mechanical properties of acrylic resins with incorporated silver-zinc zeolite-part I. Gerodontology 25: 187–194.
Cerri G, De’Gennaro M, Bonferoni M, Caramella C (2004). Zeolites in biomedical application: Zn-exchanged clinoptilolite-rich rock as active carrier for antibiotics in anti-acne topical therapy. Appl Clay Sci 27: 141–150.
Chanda S, Rakholiya K, Dholakia K, Baravalia Y (2013). Antimicrobial, antioxidant, and synergistic properties of two nutraceutical plants: Terminalia catappa L. and Colocasia esculenta L. Turk J Biol 37: 81–91.
Cohen ML (2000). Changing patterns of infectious disease. Nature 406: 762–767.
Demirci S, Ustaoğlu Z, Yılmazer GA, Sahin F, Baç N (2014). Antimicrobial properties of zeolite-X and zeolite-A ionexchanged with silver, copper, and zinc against a broad range of microorganisms. Appl Biochem Biotech 172: 1652–62.
Egger S, Lehmann RP, Height MJ, Loessner MJ, Schuppler M (2009). Antimicrobial properties of a novel silver-silica nanocomposite material. Appl Environ Microbiol 75: 2973–2976.
Galeano B, Korff E, Nicholson WL (2003). Inactivation of vegetative cells, but not spores, of Bacillus anthracis, B. cereus, and B. subtilis on stainless steel surfaces coated with an antimicrobial silver-and zinc-containing zeolite formulation. Appl Environ Microbiol 69: 4329–4331.
Ghobarkar H, Schäf O, Guth U (1999). Zeolites—from kitchen to space. Prog Solid State Ch 27: 29–73.
Gold HS, Moellering Jr RC (1996). Antimicrobial-drug resistance. N Engl J Med 335: 1445–1453.
Hagiwara Z, Hoshino S, Ishino H, Nohara S, Tagawa K, Yamanaka K (1988). Polymer article having an antibacterial property containing zeolite particles therein and the processes for producing same. Google Patents.
Holtz RD, Lima BA, Souza Filho AG, Brocchi M, Alves OL (2012). Nanostructured silver vanadate as a promising antibacterial additive to water-based paints. Nanomedicine 8: 935–940.
Huh AJ, Kwon YJ (2011). “Nanoantibiotics”: a new paradigm for treating infectious diseases using nanomaterials in the antibiotics resistant era. J Control Release 156: 128–145.
Kaali P, Strömberg E, Aune RE, Czél G, Momcilovic D, Karlsson S (2010). Antimicrobial properties of Ag + loaded zeolite polyester polyurethane and silicone rubber and long-term properties after exposure to in-vitro ageing. Polym Degrad Stab 95: 1456–1465.
Kaali P, Perez-Madrigal M, Stromberg E, Aune RE, Czel G, Karlsson S (2011). The influence of Ag + , Zn 2+ and Cu 2+ exchanged zeolite on antimicrobial and long term in vitro stability of medical grade polyether polyurethane. Express Polym Lett 5: 1028– 10
Kalaycı S, Demirci S, Sahin F (2013). Determination of antimicrobial properties of Picaridin and DEET against a broad range of microorganisms. World J Microb Biot 30: 407–411.
Kamışoğlu K, Aksoy E, Akata B, Hasirci N, Baç N (2008). Preparation and characterization of antibacterial zeolite-polyurethane composites. J Appl Polym Sci 110: 2854–2861.
Kim T, Feng Q, Kim J, Wu J, Wang H, Chen G, Cui F (1998). Antimicrobial effects of metal ions (Ag + , Cu 2+ , Zn 2+ ) in hydroxyapatite. J Mater Sci Mater Med 9: 129–134.
Kwakye‐Awuah B, Williams C, Kenward M, Radecka I (2008). Antimicrobial action and efficiency of silver‐loaded zeolite X. J Appl Microbiol 104: 1516–1524.
Lalitha M (2005). Manual on Antimicrobial Susceptibility Testing. Delhi, India: Indian Association of Medical Microbiologists.
Mah T-F, Pitts B, Pellock B, Walker GC, Stewart PS, O’Toole GA (2003). A genetic basis for Pseudomonas aeruginosa biofilm antibiotic resistance. Nature 426: 306–310.
Malachová K, Praus P, Rybková Z, Kozák O (2011). Antibacterial and antifungal activities of silver, copper and zinc montmorillonites. Appl Clay Sci 53: 642–645.
Neely AN, Maley MP (2000). Survival of enterococci and staphylococci on hospital fabrics and plastic. J Clin Microbiol 38: 724–726.
Parekh J, Jadeja D, Chanda S (2005). Efficacy of aqueous and methanol extracts of some medicinal plants for potential antibacterial activity. Turk J Biol 29: 203–210.
Rehakova M, Čuvanová S, Dzivak M, Rimár J, Gaval’Ova Z (2004). Agricultural and agrochemical uses of natural zeolite of the clinoptilolite type. Curr Opin Solid State Mater Sci 8: 397–404.
Rice LB (2009). The clinical consequences of antimicrobial resistance. Curr Opin Microbiol 12: 476–481.
Richards MJ, Edwards JR, Culver DH, Gaynes RP (1999). Nosocomial infections in medical intensive care units in the United States. Crit Care Med 27: 887–892.
Sahner K, Hagen G, Schönauer D, Reiß S, Moos R (2008). Zeolites— versatile materials for gas sensors. Solid State Ionics 179: 2416– 24
Scott E, Bloomfield SF (1990). The survival and transfer of microbial contamination via cloths, hands and utensils. J Appl Microbiol 68: 271–278.
Siedenbiedel F, Tiller JC (2012). Antimicrobial polymers in solution and on surfaces: overview and functional principles. Polymers 4: 46–71.
Taylor PW, Stapleton PD, Paul Luzio J (2002). New ways to treat bacterial infections. Drug Discov Today 7: 1086–1091.
Tinteri C, Potenza M, Rizzetto R (2012). Antimicrobial efficacy and longevity of silver+zeolite incorporating preinsulated ducts installed in real healthcare settings. J Prev Med Hyg 53: 177– 1
Top A, Ülkü S (2004). Silver, zinc, and copper exchange in a Naclinoptilolite and resulting effect on antibacterial activity. Appl Clay Sci 27: 13–19.
Valdés MG, Perez-Cordoves A, Diaz-Garcia M (2006). Zeolites and zeolite-based materials in analytical chemistry. Trends Analyt Chem 25: 24–30.
Walsh C (2000). Molecular mechanisms that confer antibacterial drug resistance. Nature 406: 775–781.
Wang S, Peng Y (2010). Natural zeolites as effective adsorbents in water and wastewater treatment. Chem Eng J 156: 11–24.
Weitkamp J (2000). Zeolites and catalysis. Solid State Ionics 131: 175–188.
Zielecka M, Bujnowska E, Kępska B, Wenda M, Piotrowska M (2011). Antimicrobial additives for architectural paints and impregnates. Prog Org Coat 72: 193–201.