Medine GÜLLÜCE, Meryem ŞENGÜL, Ahmet ADIGÜZEL, İsa KARAMAN, Ayşe Aydan KARA, Hatice ÖĞÜTÜÇÜ, Fikrettin ŞAHİN

Antimicrobial effects of Verbascum georgicum bentham ewtract

Verbascum georgicum Bentham'ın metanol ekstraktının antimikrobiyal özelliği in-vitro ortamda araştırıldı. Bir maya 4 fungus 56 bakteri türüne ait 143 mikroorganizma disk-difüzyon ve mikrodilüsyon yöntemleri kullanılarak test edildi. Verbascum georgicum Bentham'ın metanol ekstraktının Candida albicans izolatlarının hepsine ve Bacillus amyloliquefaciens, B. subtilis, B. cereus, B. pumilus, B. megaterium, B. lentimorbus, B. licheniformis, Pseudomonas putida, P. syringae, Escherichia coli türlerini içeren 10 farklı bakteri türünün 17 suşunda 37.5-300 µg/mL konsantrasyonlarında inhibisyon zonları oluşturduğu tesbit edildi. Bununla birlikte test edilen 4 fungus türünün izolatlarında antifungal aktivite göstermemiştir. Böylece, bu sonuçlara göre Verbascum georgicum Bentham'ın metanol ekstraktının antimikrobiyal özellikte bileşikler içerdiği ve bunun yeni ilaç geliştirilmesinde antimikrobiyal ajan olarak kullanılabileceği önerilebilir.

Verbascum georgicum Bentham ekstraktının antimikrobial etkileri

The methanol extract of Verbascum georgicum Bentham (Scrophulariaceae) was investigated for its in-vitro antimicrobial properties. A total of 143 microorganisms belonging to 56 bacteria and 4 fungi and a yeast species were studied using the disk-diffusion method and microdilution assays. The results indicated that the methanol extract of V. geopgicum had an inhibitory effect on the growth of all Candida albicans isolates and 17 strains in 10 different species of bacteria, namely Bacillus amyloliquefaciens, B. subtilis, B. cereus, B. pumilus, B. megaterium, B. lentimorbus, B. licheniformis, Pseudomonas putida, P. syringae and Escherichia coli, at different concentrations ranging from 37.5 to 300 µg/ml. However, it did not show antifungal activity against the isolates of the 4 fungal species tested. Thus, the results suggest that V. georgicum extract possesses compounds with antimicrobial properties that might be utilized for developing new drugs

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