In Praise of the Phytogenic Medicinal Plant Syzygium Aromaticum: A Review

Syzygium aromaticum commonly known as Clove is considered to be the most precious spice among others, which has been continued to be utilized for centuries for different biological and therapeutic purposes. It is a tropical tree which belongs to the Myrtaceae family and natively originated from Indonesia. However, in current times it is found in a few other places of the world including Brazil. Clove is viewed as perhaps the most extravagant source of phenolic mixes, for example, eugenol, eugenol acetic acid derivatives and so on. These mixtures have incredible potential for restorative, organic and other rural applications. In this review we have tried to figure out some of the important medicinal or therapeutic as well as phytobiotic and agricultural utilizations of the products prepared from Clove. We have tried to give an extra emphasis on the application of clove as a product of herbal contraception however for this purpose dose of the extract (either aqueous or ethanolic) of clove plays the vital role in this case. Although for establishing or making clove products commercially available as a safe product for herbal contraception or other medicinal impacts, more studies are required, and it could open a new era in the field of herbal medicine that would be much safer and feasible.

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Mishra RK, Singh SK. 2013. Reproductive effects of lipid soluble components of Syzygium aromaticum flower bud in male mice. J Ayurveda Integr Med, 2013; 4: 94-8.
Andaya LY. 1993. "Cultural State Formation in Eastern Indonesia". In Reid, Anthony (ed.). Southeast Asia in the early modern era: trade, power, and belief. Cornell University Press 1993; ISBN 978-0-8014-8093-5.
Lape PV. 2010. Political dynamics and religious change in the late pre-colonial Banda Islands, Eastern Indonesia. World Archaeology, 2010; 32(1): 138–155.
Kingwell-Banham E. 2019. "World's oldest clove? Here's what our find in Sri Lanka says about the early spice trade". The Conversation, 2019.
Turner J. 2004. Spice: The History of a Temptation. Vintage Books, 2004; pp. xxvii–xxviii. ISBN 978-0-375-70705-6.
Worrall S. 2012. The world's oldest clove tree. BBC News Magazine, 2012.
Kamatou GP, Vermaak I, Viljoen AM. 2012. Eugenol from the remote Maluku Islands to the international market place: a review of a remarkable and versatile molecule. Molecules, 2012; 17(6): 6953-6981.
Filho GA, Cesar JO, Ramos JV. 2013. Cravo from India. Itabuna: CEPLAC, 2013. Available from: http://www.ceplac.gov.br/ radar.htm.
Oliveira RA, Oliveira FF, Sacramento CK. 2007. Essential oils: prospects for agribusiness spices in Bahia. Bahia Agric, 2007; 8(1): 46-48.
Oliveira RA, Reis TV, Sacramento CK, Duarte LP, Oliveira FF. 2009. Volatile chemical constituents of rich spices in eugenol. Rev Bras Farmacognosia, 2009; 19(3): 771-775.
Diego Francisco CR, Claudia RFS, Wanderley PR. 2014. Clove (Syzygium aromaticum): a precious spice. Asian Pac J Trop Biomed, 2014; 4(2): 90-96.
Shan B, Cai YZ, Sun M, Corke H. 2005. Antioxidant capacity of 26 spice extracts and characterization of their phenolic constituents. J Agric Food Chem, 2005; 53(20): 7749-7759.
Jirovetz L, Buchbauer G, Stoilova I, Stoyanova A, Krastanov A, Schmidt E. 2006. Chemical composition and antioxidant properties of clover leaf essential oil. J Agric Food Chem, 2006; 54(17): 6303-6307.
Neveu V, Perez-Jiménez J, Vos F, Crespy V, du Chaffaut L, Mennen L, et al. 2010. Phenol-Explorer: an online comprehensive database on polyphenol contents in foods. Database, 2010; bap024.
Gülçina Ì, Şatb İG, Beydemira Ş, Elmastaşc M, Küfrevioglu Öİ. 2004. Comparison of antioxidant activity of clove (Eugenia caryophylata Thunb) buds and lavender (Lavandula stoechas L.). Food Chem, 2004; 8(3): 393-400.
Abdel-Wahhab MA, Aly SE. 2005. Antioxidant property of Nigella sativa (black cumin) and Syzygium aromaticum (clove) in rats during aflatoxicosis. J Appl Toxicol, 2005; 25(3): 218-223.
Mehta KD, Garg GR, Mehta AK, Arora T, Sharma AK, Khanna N. 2010. Reversal of propoxur-induced impairment of memory and oxidative stress by 4’-chlorodiazepam in rats. Naunyn Schmiedebergs Arch Pharmacol, 2010; 381(1): 1-10.
Halder S, Mehta AK, Kar R, Mustafa M, Mediratta PK, Sharma KK. 2011. Clove oil reverses learning and memory deficits in scopolaminetreated mice. Planta Med, 2011; 77(8): 830-834.
Chatterjee D, Bhattacharjee P. 2013. Comparative evaluation of the antioxidant efficacy of encapsulated and un-encapsulated eugenol-rich clove extracts in soybean oil: shelf-life and frying stability of soybean oil. J Food Eng, 2013; 117(4): 545-550.
Sofia PK, Prasad R, Vijay VK, Srivastava AK. 2007. Evaluation of antibacterial activity of Indian spices against common foodborne pathogens. Int J Food Sci Technol, 2007; 42(8): 910-915.
Burt SA, Reinders RD. 2003. Antibacterial activity of selected plant essential oils against Escherichia coli O157:H7. Lett Appl Microbiol, 2003; 36(3): 162-167.
Pérez-Conesa D, McLandsborough L, Weiss J. 2006. Inhibition and inactivation of Listeria monocytogenes and Escherichia coli O157:H7 colony biofilms by micellar-encapsulated eugenol and carvacrol. J Food Prot, 2006; 69(12): 2947-2954.
Rana IS, Rana AS, Rajak RC. 2011. Evaluation of antifungal activity in essential oil of the Syzygium aromaticum (L.) by extraction, purification and analysis of its main component eugenol. Braz J Microbiol, 2011; 42(4): 1269-1277.
Devi KP, Nisha SA, Sakthivel R, Pandian SK. 2010. Eugenol (an essential oil of clove) acts as an antibacterial agent against Salmonella typhi by disrupting the cellular membrane. J Ethnopharmacol, 2010; 130(1): 107-115.
Chami F, Chami N, Bennis S, Trouillas J, Remmal A. 2004. Evaluation of carvacrol and eugenol as prophylaxis and treatment of vaginal candidiasis in an immunosuppressed rat model. J Antimicrob Chemother, 2004; 54(5): 909-914.
Ali SM, Khan AA, Ahmed I, Musaddiq M, Ahmed KS, Polasa H, et al. 2005. Antimicrobial activities of eugenol and cinnamaldehyde against the human gastric pathogen Helicobacter pylori. Ann Clin Microbiol Antimicrob, 2005; 4: 20. https://www.herbwisdom.com/herb-cloves.html
Li HY, Lee BK, Kim JS, Jung SJ, Oh SB. 2008. Eugenol inhibits ATPinduced P2X currents in trigeminal ganglion neurons. Korean J Physiol Pharmacol, 2008; 12(6): 315-321.
Ohkubo T, Shibata M. 1997. The selective capsaicin antagonist capsazepine abolishes the antinociceptive action of eugenol and guaiacol. J Dent Res, 1997; 76(4): 848-851.
Daniel AN, Sartoretto SM, Schimidt G, Caparroz-Assef SM, Bersani-Amado CA, Cuman RK. 2009. Anti-inflamatory and antinociceptive activities of eugenol essential oil in experimental animal models. Rev Bras Farmacogn, 2009; 19(1B): 212-217.
Kurokawa M, Hozumi T, Basnet P, Nakano M, Kadota S, Namba T, et al. 1998. Purification and characterization of eugeniin as an antiherpesvirus compound from Geum japonicum and Syzygium aromaticum. J Pharmacol Exp Ther 1998; 284(2):728-735.
Kurokawa M, Nagasaka K, Hirabayashi T, Uyama S, Sato H, Kageyama T, et al. 1995. Efficacy of traditional herbal medicines in combination with acyclovir against herpes simplex virus type 1 infection in vitro and in vivo. Antiviral Res, 1995; 27(1-2): 19-37.
Mishra RK, Singh SK. 2008. Safety assessment of Syzygium aromaticum flower bud (clove) extract with respect to testicular function in mice. Food Chem Toxicol, 2008; 46:3333-3338.
Rajalakshmi M. 1992. Regulation of male fertility: Epididymis as a potential extra-gonadal site. In: Ghosh D, Sengupta J, editors. Frontiers in reproductive physiology. New Delhi: Wiley Eastern Limited, 1992; 63-66.
Buch JG, Dikshit RK, Mansuri SM. 1988. Effect of certain volatile oils on human spermatozoa. Indian J Med Res, 1988; 87:361-363.
Lo KC, Lamb DJ. 2004. The testis and male accessory sex organs. In: Strauss LF, Barbieri RL, editors. Yen and Jaffe’s Reproductive Endocrinology. Pennsylvania: Elsevier Saunders, 2004; 5: 367-87.
Bhakta S, Awal A, Das SK. 2019. Herbal contraceptive effect of Abrus precatorius, Ricinus communis, and Syzygium aromaticum on anatomy of the testis of male Swiss albino mice. J Adv. Biotechnol. Exp. Ther., 2019; 2(2): 36-43.
Dehghani F, Heshmatpour A, Panjehshahin MR, Talaei-Khozani T. 2012. Toxic effects of water/alcoholic extract of Syzygium aromaticum on sperm quality, sex hormones and reproductive tissues in male mouse. IUFS J Biol, 2012; 71(2): 95-102.
Tajuddin AS, Latif A, Qasmi IA. 2003. Aphrodisiac activity of 50% ethanolic extracts of Myristica fragrans Houtt. (nutmeg) and Syzygium aromaticum (L) Merr. and Perry. (clove) in male mice: a comparative study. BMC Complementary and Alternative Medicine, 2003; 46: 3333-3336.
Park IK, Shin SC. 2005. Fumigant activity of plant essential oils and components from garlic (Allium sativum) and clove bud (Eugenia caryophyllata) oils against the Japanese termite (Reticulitermessperatus Kolbe). J Agric Food Chem, 2005; 53(11): 4388-4392.
Eamsobhana P, Yoolek A, Kongkaew W, Lerdthusnee K, Khlaimanee N, Parsartvit A, et al. 2009. Laboratory evaluation of aromatic essential oils from thirteen plant species as candidate repellents against Leptotrombidium chiggers (Acari: Trombiculidae), the vector of scrub typhus. Exp Appl Acarol, 2009; 47(3): 257-262.
Kafle L, Shih CJ. 2013. Toxicity and repellency of compounds from clove (Syzygium aromaticum) to red imported fire ants Solenopsis invicta (Hymenoptera: Formicidae). J Econ Entomol, 2013; 106(1): 131-135.
Zhang QH, Schneidmiller RG, Hoover DR. 2013. Essential oils and their compositions as spatial repellents for pestiferous social wasps. Pest Manag Sci, 2013; 69(4): 542-552.