Fulya COŞAN, Meyancı Güniz KÖKSAL, Hüseyin ÖZ

Tavşanlarda HCI ile oluşturulan akut akciğer hasarında intravenöz ve intratrakeal lidokainin hemodinami ve kompliyans üzerine olan etkilerinin karşılaştırılması

Çalışmamızda, sağlıklı tavşan akciğerinde intratrakeal (İT) hidroklorik asit (HCl) ile oluşturulan akut akciğer hasarında (ALI) değişik miktarlarda İV ve intratrakeal (İT) lidokain kullanımının ortalama arter basıncı (OAB), kalp atım hızı (KAH) ve kompliyans üzerine olan etkilerini karşılaştırmayı amaçladık. Prospektiv, rasgele olarak yaptığımız çalışmamızda 20 Yeni Zelanda tavşanı 4 eşit gruba ayrıldı (n:5). Ketaminle sedasyon sağlanan tavşanlara trakeostomi açıldı, basınç kontrollü modda parametreler, FiO2 :1.0, PIP:12 cmH2O, PEEP:5 cmH2O, solunum frekansı başlangıç PaCO2 değeri 35-40 mmHg olacak şekilde ayarlanarak mekanik ventilasyona başlandı. Arterven kanülasyonları yapılarak ilk ölçümler (OAB, KAH, kompliyans) kaydedildi. Tüm hayvanlara 2 mL/kg HCl İT verildi ve 5 dk sonra; 1. gruba: lidokain 2 mg/kg, İV, 2. gruba: lidokain 2 mg/kg, İT, 3. gruba: lidokain 4 mg/kg İV, 4. gruba: lidokain 4 mg/kg, İT uygulandı. Lidokain verildikten 5 dk sonra ve çalışmanın sonunda plazma ve BAL lidokain seviye tayini için örnekler alındı. OAB, II. grupta 60 ve 120. dk'larda diğer gruplara göre yüksek (p

Comparison of effects of intravenous and intra-tracheal lidocaine on hemodynamy and compliance in HCI induced-acute lung injury in rabbits

In this study, we aimed to compare the effects of different amounts of intravenous and intratracheal (IT) lidocaine to mean arterial pressure (MAP), heart rate (HR) and lung compliance (C) in an experimental IT HCl-induced acute lung injury (ALI) model in rabbits. 20 New Zealand rabbits were randomly divided into 4 groups n=5 for each group). After sedation with keta-mine, tracheostomy was performed and mechanical ventilation was initiated in pressure control mode with parameters; FiO2:1.0, PIP:12 cmH2O, PEEP: 5 cmH2O and respiratory rate was adjusted as initial PaCO2 to be 35-40 mmHg. Initial measurements were recorded after arterial and venous cannulation was done (MAP, HR, C). All animals were received 2 mL/kg IT HCl and 5 min later; group 1, was administered 2 mg/kg IV lidocaine, group 2, 2 mg/kg IT lidocaine, group 3, 4 mg/kg IV lidocaine, group 4, 4 mg/kg IT lidocaine. After 5 min of lidocaine application and at the end of the study, plasma and BAL samples were taken in order to measure lidocaine level. In group 2 MAP was higher at 60th and 120th min, when compared with other groups (p

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