Subakut sklerozan panansefalit (SSPE)

Subakut sklerozan panansefalit (SSPE), nörodejeneratif bir hastalıktır. Kızamık virüsünün beyinde oluşturduğu süregen enfeksiyon ile belirgindir. Virüsün süregenliğinin ve reaktivasyonunun mekanizmaları bilinmemektedir. Hastalarda, genellikle davranış değişiklikleri, miyoklonus, demans, görme bozukluğu, piramidal ve ekstrapiramidal bulgular vardır. Hastalığın henüz etkili ve kesin bir tedavisi yoktur. Gelişmiş ülkelerde sıklığında azalma olmakla birlikte, gelişmekte olan ülkelerde sık görülmektedir. Kızamığa karşı etkin aşılama, bu hastalık için şu andaki tek çözümdür. Bu yazıda SSPE ile ilgili kapsamlı bilgi verilmesi amaçlandı.

Subacute sclerosing panencephalitis (SSPE)

Subacute sclerosing panencephalitis (SSPE) is a neurodegenerative disease with a poor prognosis. It is characterized by the persistent infection of the brain by the measles virus. Mechanisms causing persistence and reactivation of measles virus in SSPE are unknown. Patients usually have behavioral changes, myoclonus, dementia, visual disturbances, and pyramidal and extrapyramidal signs. No treatment has a proven role. A decline in frequency has been noticed in most of the developed countries, whereas it continues to be high in developing countries. Effective immunization against measles is the only solution presently available to the problem of this dreaded disease. We aimed to give an overall review on SSPE in this paper.

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