Penisilin ve diğer beta laktam antibiyotik alerjilerinde son görüşler Çağrılı Editör

Beta laktamlar bulundukları zamandan beri genel pediatri uygulamasında yaygın olarak kullanılmışlardır Fakat beta laktamların yol açtığı alerjik tepkiler ilaçlarla oluşan immünolojik tepkimelerin en sık sebebi olup bu ilaçların kullanılması gerektiğinde hem doktorlarda hem de ailelerde kaygıya yol açmaktadır Maalesef bu tepkimeler beta laktam antibiyotikleri oluşturan tüm ilaçlarla; penisilinler sefalosporinler aztreonam ve karbapenemler hepsi ile oluşabilir Ailelerin ve doktorların penisilin alerjisinden kaynaklanan kaygıları beta laktam antibiyotikler için gerçekten gerekli olsa da günlük uygulamalarda kullanımını kısıtlamakta ve böylece arzu edilmeyen veya vankomisin gibi daha pahalı antibiyotiklerin kullanımına yol açmaktadır Bütün bu sebeplerden dolayı bütün doktorların özellikle çocuk doktorlarının beta laktam alerjisini her yönüyle doğru bilmeleri gereklidir Türk Ped Arş 2008; 43: 36 9 Anahtar kelimeler: Anafilaksi beta laktam antibiyotikler penisilin

Anahtar Kelimeler:

Anafilaksi, beta-laktam antibiyotikler, penisilin

Current opinions on penicilin and other beta lactam antibiotic allergies Invited Editor

Beta lactam antibiotics have been commonly used in general pediatrics practice since their inventions But allergic reactions to beta lactams represent the most frequent cause of immunological drug reactions and lead to concerns both in doctors and parents when they are used Unfortunately these reactions may be induced by all beta lactams available including penicillins cephalosporins aztreonam and carbapenems Parents’ and clinicians’ concerns about penicillin allergy constrains beta lactam antibiotic usage in daily practice and therefore increase undesirable and more expensive antibiotic use such as vancomycin Because of these reasons all physicians especially pediatricians should know all aspects of beta lactam allergies Turk Arch Ped 2008; 43: 36 9 Key words: Anaphilaxy beta lactam antibiotic penicillin

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Penisilin, beta-laktam alerjileri