Penisilin ve diğer beta-laktam antibiyotik alerjilerinde son görüşler

Beta-laktamlar bulundukları zamandan beri genel pediatri uygulamasında yaygın olarak kullanılmışlardır. Fakat beta-laktamların yol açtığı alerjik tepkiler, ilaçlarla oluşan immünolojik tepkimelerin en sık sebebi olup bu ilaçların kullanılması gerektiğinde hem doktorlarda hem de ailelerde kaygıya yol açmaktadır. Maalesef, bu tepkimeler beta-laktam antibiyotikleri oluşturan tüm ilaçlarla; penisilinler, sefalosporinler, aztreonam ve karbapenemler, hepsi ile oluşabilir. Ailelerin ve doktorların penisilin alerjisinden kaynaklanan kaygıları beta-laktam antibiyotikler için gerçekten gerekli olsa da günlük uygulamalarda kullanımını kısıtlamakta ve böylece arzu edilmeyen veya vankomisin gibi daha pahalı antibiyotiklerin kullanımına yol açmaktadır. Bütün bu sebeplerden dolayı bütün doktorların, özellikle çocuk doktorlarının beta-laktam alerjisini her yönüyle doğru bilmeleri gereklidir.

Current opinions on penicilin and other beta-lactam antibiotic allergies

Beta-lactam antibiotics have been commonly used in general pediatrics practice since their inventions. But, allergic reactions to beta-lactams represent the most frequent cause of immunological drug reactions and lead to concerns both in doctors and parents when they are used. Unfortunately, these reactions may be induced by all beta-lactams available, including penicillins, cephalosporins, aztreonam and carbapenems. Parents’ and clinicians’ concerns about penicillin allergy constrains beta-lactam antibiotic usage in daily practice and therefore increase undesirable and more expensive antibiotic use, such as vancomycin. Because of these reasons all physicians especially, pediatricians should know all aspects of beta-lactam allergies.

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