Kolestatik tipte sarılık deride krutlu skuamlı makülo papüler tarzda kaşıntılı peteşial döküntüler anemi hepatosplenomegali ve multisistem organ tutulumu olan 2 hastaya deri biyopsisinde S 100 boyanan histiositlerin gösterilmesi ile Langerhans hücreli histiositoz tanısı kondu Bu 2 olgu nedeniyle klinik ve biyokimyasal olarak kolestaz bulguları olan hastaların ayırıcı tanısında Langerhans hücreli histiositozun da düşünülmesi gerektiğini hatırlatmak istedik Anahtar kelimeler: Langerhans Hücreli Histiositoz Kolestaz Çocuk

Two cases of Langerhans cell histiocytosis who had multiorgan involvement with obstructive jaundice anemia and hepatosplenomegaly painful ulceration purulent exudation squamous and maculopapular rash in the skin were presented The diagnosis of Langerhans cell histiocytosis was made by skin biopsies that showed the presence of S 100 staining cells We suggest that the diagnosis of Langerhans cell histiocytosis should be considered in patients presenting with clinical and biochemical evidence of cholestasis Key words: Langerhans Cell Histiocytosis Cholestasis Children