Çocuklarda sık relaps gösteren ve steroide bağımlı nefrotik sendromun öngördürücüleri

Amaç: Steroide duyarlı nefrotik sendromu olan çocuklarda sık relapsların ve steroid bağımlılığının öngördürücülerini belirlemek amaçlandı.Gereç ve Yöntemler: Üçüncül bir merkezde 2003 ile 2015 yılları arasında steroide duyarlı nefrotik sendrom tanısı ile nefroloji kliniğinekaydedilmiş olan ve hastalık başlangıcından sonra en az bir yıl izlenen altı ay ile 18 yaş arasındaki bütün çocuklar çalışmaya alınmıştır.Bulgular: Hastalık başlangıcından itibaren en az bir yıl izlenmiş olansteroide duyarlı nefrotik sendrom tanılı 277 hasta çalışmaya alındı.Nadir relaps gösteren 157 hasta ve sık relaps gösteren 120 olgu çalışmaya alındı (sık relaps gösteren ya/ya da steroid bağımlı). Nadirrelaps gösterenlerle karşılaştırıldığında, sık relaps gösterenlerde, hastalık başlangıç yaşı anlamlı derecede daha küçüktü (51,53±40,42 vs.61,97±40,66 ay; p=0,035), ilk relapsa kadar geçen süre daha kısaydı[ilk tedavi başlangıcından ilk relapsa kadar geçen süre (8,65±11,99 vs.23,46±24,05 ay; p

Predictors of frequent relapsing and steroid-dependent nephrotic syndrome in children

Aim: To determine the predictors of frequent relapses and steroid dependency in children with steroid-sensitive nephrotic syndrome. Material and Methods: All children aged six months to 18 years with steroid-sensitive nephrotic syndrome registered in the nephrology clinic between 2003 and 2015 at a tertiary center who were followed up for at least 1year after onset were included in the study. Results: Two hundred seventy-seven patients with steroid-sensitive nephrotic syndrome who were followed up for at least 1 year from onset of disease were included. There were 157 infrequent relapsers and 120 frequent relapsers (frequent relapses and or steroid-dependent). Compared with infrequent relapsers, frequent relapsers had a significantly lower age at onset (51.53±40.42 vs. 61.97±40.66 months; p=0.035), lesser time for first relapse (time from the start of initial treatment to first relapse (8.65±11.99 vs. 23.46±24.05 months; p

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