Soheila AMINIMOGHADDAM, Marziyeh MOHAMMADI, Saeid REZAEI

Polyp-confined Endometrial Serous Carcinoma Simultaneity with Cervical Adenocarcinoma: A Case Report

T he most common gynecologic cancer is endometrial adenocarcinoma, which presents mostly in postmenopausal women. There are two subtypes of endometrial cancer. Uterine serous carcinoma (USC) as a rare and aggressive type is associated with obesity and hypertension, and unlike the endometrioid type, is not associated with hyperestrogenism and atypical endometrial hyperplasia. Endometrial polyps would be a common finding in old women, and its likelihood with the presence of hypertension, tamoxifen therapy and obesity rises even more. Approximately 5.42% of the endometrial polyps contain the premalignant or malignant disease, but commonly, they are considered to be benign lesions. Serous carcinoma (USC) is less common malignant lesions in endometrial polyps. Concomitant endometrial cancers with cervical cancer in gynecologic oncology are very rare conditions, and to date, few cases have been reported. It even becomes rarer when we have a condition in which endometrial cancer is limited in the polyp. In this case, we report a cervical adenocarcinoma and simultaneous detection of endometrial serous carcinoma within the confines of polyp without the involvement of myometrium and other parts of the endometrium, which is unusual and rare. Treatment strategies in these cases are remaining controversial. Adjuvant therapy, radiation therapy and surgery have been debated, and everyone reported to be efficient in specific conditions. In our case, we decided to start adjuvant chemotherapy after surgical management, and fortunately, now, she is in good condition with well follow up results.

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