Pediatrik Hodgkin lenfoma: Yeni yapılanmakta olan bir onkoloji merkezinde epidemiyolojik özellikler ve erken tedavi sonuçları
AMAÇ Pediatrik Hodgkin lenfoma tanılı hastaların karakteristikleri ve tedavi yanıtlarının incelenmesi.GEREÇ VE YÖNTEM 2003-2006 yılları arasında Kocaeli Üniversitesi Pediatrik Onkoloji Grubu tarafından tedavi edilen Hodgkin lenfoma tanılı 18 yaş altı hastalar (9 erkek, 4 kız; ort. yaş 9.2±3.5; dağılım 4-15) geriye dönük olarak değerlendirildi.BULGULAR En sık saptanan histopatolojik alt tip (%54) mikst selüler Hodgkin lenfoma idi. Olguların %69'u erken evre hastalıkla (evre I, II) başvurmuşlardı. On iki olguya ABVD, bir hastaya ise OEPA/COPP rejimi uygulandı. Hastaların %83'ünde 2. kürden sonra tam yanıt elde edildi. Olguların 11'ine kemoterapi sonrası tutulu alan radyoterapisi, 2 olguya ise “bulky” bölgeye radyoterapi uygulandı. Radyoterapi dozları evreye ve kemoterapi cevabına göre değişmekle birlikte ortanca 2000 (1500-3000) cGy'di. Dört yıllık genel ve olaysız sağkalım oranları %87.5 olarak saptandı.SONUÇ Merkezimizde uygulanan evre ve KT yanıtına dayalı kombine tedavi modelimizin erken sonuçları, diğer merkezlerin sonuçlarıyla benzer oranda başarılıdır.
Pediatric Hodgkin lymphoma: epidemiologic characteristics and early treatment results in a new oncology center
OBJECTIVES To evaluate patient characteristics and treatment results of pediatric patients with Hodgkin lymphoma. METHODS Hodgkin lymphoma patients (9 males, 4 females; mean age 9.2±3.5; range 4 to 15 years) at pediatric age group (
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- ISSN: 1300-7467
- Başlangıç: 2015
- Yayıncı: Ali Cangül
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