Gökhan ÖZYİĞİT, Branislav JEREMİC, Pavol DUBİNSKY, Nenad FİLİPOVİC

Optimal Administration Frequency of Cisplatin Concurrently With Radical Radiotherapy in the Definitive Treatment of Locally Advanced, Inoperable Squamous Cell Cancer of the Head and Neck. Still Obscured by Clouds?

Here we present a summary of existing evidence from meta-analyses and systematic reviews in thesetting of locally advanced, inoperable squamous cell cancer of the head and neck, treated with radicalradiotherapy and concurrent cisplatin therapy either weekly or every 3 weeks. Taken together, the dataseem to indicate that there is no difference in major outcomes, including toxicity. However, caution inthe interpretation of the data should be exercised due to poor quality of original studies, none of whichwas a prospective randomized phase III trial. Practicing clinicians should continue using their best judgment about the most appropriate treatment option in this setting, taking into account both the existingevidence and also various patient and tumor characteristics.

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