Züleyha AKGÜN, Aydın ÇAKIR

Comparison of Anisotropic Analytical Algorithm and Acuros XB Calculation Algorithms on Intensity-modulated Radiotherapy and Volumetric Modulated Arc Therapy Techniques for Nasal Cavity and Paranasal Sinus Tumors: Effects on Integral Radiation Dose

OBJECTIVEThis study aims to investigate the dosimetric effects of Acuros XB (AXB) and Anisotropic Analyticalalgorithms (AAA) on intensity-modulated radiotherapy (IMRT) and volumetric modulated arc therapy(VMAT) techniques for nasal cavity and paranasal sinus tumors.METHODSThis study included 10 patients with the nasal cavity and paranasal sinus tumors, and 7-field non-coplanar IMRT plan and VMAT plans were generated with 6-MV photon beams specially selected for eachpatient anatomy. The effects on planning target volume (PTV) and organ-at-risk (OAR) were evaluatedusing AXB and AAA in each treatment technique to compare the accuracy of the calculation.RESULTSConformity Index (CI) values for PTV were found to be 1.02±0.02 and 1.03±0.03 for VMATAAA andVMATAXB plans, respectively and 1.18±0.03 and 1.20±0.02 for IMRTAAA and IMRTAXB plans, respectively.Regarding heterogeneity index (HI) values, VMATAAA and VMATAXB plans (0.025±0.02; 0.029±0.02)were found to have better HI values than IMRTAAA and IMRTAXB plans (0.246±0.02; 0.335±0.03). Depending on the technique and algorithm used, a dose difference of 4%-14% was detected between PTVDmin values.CONCLUSIONThe selection of AXB algorithm in treatment regions with high tissue heterogeneity will give more accurate dose calculation results for PTV and healthy tissues.

PDF

___

1. Huang D, Xia P, Akazawa P, Akazawa C, Quivey JM, Verhey LJ, et al. Comparison of treatment plans using intensity-modulated radiotherapy and three- -dimensional conformal radiotherapy for paranasal sinus carcinoma. Int J Radiat Oncol Biol Phys 2003;56(1):158−68.
2. Sheng K, Molloy JA, Larner JM, Read PW. A dosimetric comparison of non-coplanar IMRT versus Helical Tomotherapy for nasal cavity and paranasal sinus cancer. Radiother Oncol 2007;82(2):174−8.
3. Jeong Y, Lee SW, Kwak J, Cho I, Yoon SM, Kim JH, et al. A dosimetric comparison of volumetric modulated arc therapy (VMAT) and non-coplanar intensity modulated radiotherapy (IMRT) for nasal cavity and paranasal sinus cancer. Radiat Oncol 2014;9:193.
4. D’Souza WD, Rosen II. Nontumor integral dose variation in conventional radiotherapy treatment planning. Med Phys 2003;30(8):2065−71.
5. Vassiliev O, Wareing T, McGhee J, Failla G, Salehpour M, Mourtada F. Validation of a New Grid Based Blotzmann Equation Solver for Dose Calculation in Radiotherapy with Photon Beams. Phys Med Biol 2010;55(3):581−98.
6. Bush K, Gagne IM, Zavgorodni, Ansbacher S, Beckham W. Dosimetric Validation of Acuros XB with Monte Carlo Methods for Photon Dose Calculations. Med Phys 2011;38(4):2208−21.
7. Hoffmann L, Jørgensen MB, Muren LP, Petersen JB. Clinical Validation of the Acuros XB Photon Dose Calculation Algorithm, a Grid-Based Boltzmann Equation Solver. Acta Oncol 2012;51(3):376−85.
8. Han T, Mikell J, Salehpour M, Mourtada F. Dosimetric Comparison of Acuros XB Deterministic Radiation Transport Method with Monte Carlo and Model Based Convolution Methods in Heterogeneous Media. Med Phys 2011;38(5):2651−64.
9. Fogliata A, Nicolini G, Clivio A, Vanetti E, Cozzi L. Critical appraisal of Acuros XB and Anisotropic Analytic Algorithm dose calculation in advanced nonsmall-cell lung cancer treatments. Journ Clin Oncol 2012;83(5):1587−95.
10.Fogliata A, Nicolini G, Clivio A, Vanetti E, Cozzi L. On the dosimetric impact of inhomogeneity management in the Acuros XB algorithm for breast treatment. Radiat Oncol 2011;6(1):103.
11.Han T, Mourtada F, Kisling K, Mikell J, Followill D, Howell R. Experimental Validation of Deterministic Acuros XB Algorithm for IMRT and VMAT Dose Calculation with Radiological Physics Center’s Head and Neck Phantom. Med Phys 2012;39(4):2193−2202.
12.Huang B, Wu L, Lin P, Chen C. Dose calculation of Acuros XB and Anisotropic Analytical Algorithm in lung stereotactic body radiotherapy treatment with flattening filter free beams and the potential role of calculation grid size. Radiat Oncol 2015;10:53.
13.Cakir A. Dosimetric comparison of Anisotropic Analytical Algorithm and Acuros XB in Stereotactic Body Radiotherapy and effect of calculation grid size. Turk J Oncol 2017;32(3):100–5.
14.Chung H, Jin H, Palta J, Suh TS, Kim S. Dose variations with varying calculation grid size in head and neck IMRT. Phys Med Biol 2006;51(19):4841−56.
15.Mittauer K, Lu B, Yan G, Kahler D, Gopal A, Amdur R, et al. A study of IMRT planning parameters on planning efficiency, delivery efficiency, and plan quality. Med Phys 2013;40(6):061704.
16.Kan M, Leung L, Yu P. Verification and Dosimetric Impact of Acuros XB Algorithm on Intensity Modulated Stereotactic Radiotherapy for Locally Persistent Nasopharyngeal Carcinoma. Med Phys 2012; 39(8):4705−14.
17.Suresh R, Kevin R, Shyam P, Terry L, Daniel R, Christopher B. Acuros XB Algorithm vs. Anisotropic Analytical Algorithm: A Dosimetric study using hetergeneous phantom and computed tomography (CT) data sets of esophageal cancer patients. Journal of Cancer Therapy 2013;4(1):138−44.
18.Cakir A, Akgun Z. Dosimetric comparison of integral radiation dose: Anisotropic Analytical Algorithm and Acuros XB in Breast Radiotherapy. Int Journ of Medical Phys, Clin Eng and Radiat Oncol 2019;8:57−67.
19.Padmanaban S, Warren S, Walsh A, Partridge M, Hawkins A. Comparison of Acuros (AXB) and Anisotropic Analytical Algorithm (AAA) for dose calculation in treatment of oesophageal cancer: effects on modelling tumour control probability. Radiat Oncol 2014;9:286.
20.Guckenberger M, Richter A, Krieger T, Wilbert J, Baier K, Flentje M. Is a single arc sufficient in volumetricmodulated arc therapy (VMAT) for complex-shaped target volumes? Radiother Oncol 2009; 93(2):259−65.