Gülen DOĞUSOY, M. Şefik İĞDEM, M. Mazhar ÇELİKOYAR, Okan FALAY, Erkan AKTAN, Gürsel TURGUT

Case Report: Oropharyngeal Cancer in a 4-Year-Old Child

Oropharyngeal squamous cell carcinoma is very uncommon among young children. This is a case report of a 4-year-old boy who was referred from another country with a history of a left-sided neck massresected 5 months prior to his arrival. Three pathologists gave 3 different pathological diagnoses fromthe same specimen. A computed tomography scan of the neck indicated a mass located at the base ofthe tongue. A lesion biopsy confirmed a diagnosis of poorly differentiated carcinoma with p16 positivity and focal human papillomavirus positivity. The decision of the multidisciplinary board was to useradiation treatment as single-modality therapy. The patient completed the treatment and almost 5 yearshave passed uneventfully. This very rare occurrence of squamous cell carcinoma appears to have beenresolved without any major consequences.

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1. Marcus KJ, Tishler RB. Head and neck carcinomas across the age spectrum: epidemiology, therapy, and late effects. Semin Radiat Oncol 2010;20(1):52–7.
2. van Monsjou HS, Wreesmann VB, van den Brekel MW, Balm AJ. Head and neck squamous cell carcinoma in young patients. Oral Oncol 2013;49(12):1097–102.
3. Morris LG, Patel SG, Shah JP, Ganly I. Squamous cell carcinoma of the oral tongue in the pediatric age group: a matched-pair analysis of survival. Arch Otolaryngol Head Neck Surg 2010;136(7):697–701.
4. Rednam S, Hicks J, Levy ML, Pappo AS. Metastatic squamous cell carcinoma of the oropharynx in a child with a mutation in the Connexin 26 gene. J Pediatr Hematol Oncol 2011;33(5):387–9.
5. Stransky N, Egloff AM, Tward AD, Kostic AD, Cibulskis K, Sivachenko A, et al. The mutational landscape of head and neck squamous cell carcinoma. Science 2011;333(6046):1157–60.
6. Barwad A, Sood S, Gupta N, Rajwanshi A, Panda N, Srinivasan R. Human papilloma virus associated head and neck cancer: A PCR based study. Diagn Cytopathol 2012;40(10):893–7.
7. Koskimaa HM, Waterboer T, Pawlita M, Grénman S, Syrjänen K, Syrjänen S. Human papillomavirus genotypes present in the oral mucosa of newborns and their concordance with maternal cervical human papillomavirus genotypes. J Pediatr 2012;160(5):837–43.
8. Lydiatt WM, Patel SG, O’Sullivan B, Brandwein MS, Ridge JA, Migliacci JC, et al. Head and Neck cancers-major changes in the American Joint Committee on cancer eighth edition cancer staging manual. CA Cancer J Clin 2017;67(2):122–37.
9. Haddad R, O’Neill A, Rabinowits G, Tishler R, Khuri F, Adkins D, et al. Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a randomised phase 3 trial. Lancet Oncol 2013;14(3):257–64.
10.Olgun Y, Erdag TK, Aydin B, Mutafoglu K, Ozer E, Ikiz AO, et al. Pediatric laryngeal cancer with 5-year follow up: case report. Int J Pediatr Otorhinolaryngol 2013;77(7):1215–8.
11.Ingersoll L, Woo SY, Donaldson S, Giesler J, Maor MH, Goffinet D, et al. Nasopharyngeal carcinoma in the young: a combined M.D. Anderson and Stanford experience. Int J Radiat Oncol Biol Phys 1990;19(4):881–7.