Melek Gamze AKSU, Mine GENÇ, Kamil KARAALİ, Alper Tunga DERİN, Havva Serap TORU, Beyza Şirin ÖZDEMİR

A Case of Epithelial–Myoepithelial Carcinoma in the Nasal Cavity Treated with Definitive Chemoradiotherapy

Epithelial–myoepithelial carcinoma (EMC) is an uncommon neoplasm that is predominantly seen inmajor salivary glands. Although it is considered as low grade, the high recurrence rate is quite common.EMC of the nasal cavity is extremely rare. A case of EMC detected in the nasal cavity is reported. A44-year-old woman presented with a 1-year history of nasal congestion and bleeding. Magnetic resonance imaging (MRI) revealed a 4×4 cm necrotic expansile lesion involving the bilateral nasal cavity,extending to the nasopharynx, oral cavity, maxillary sinus, and ethmoid cells. The patient was found tobe inoperable since complete surgical resection was not possible, and excisional biopsy was performed.Histopathological and immunohistochemical analyses led to a diagnosis of EMC. Definitive radiotherapy(RT) with concomitant cisplatin was applied. After 4 years, the patient is asymptomatic, and MRI showeda stable status with no progression. EMC is rarely seen in the nasal cavity. If possible, the first treatmentmodality should be surgery. The role of RT is controversial. To the best of our knowledge, this is the onlycase treated with definitive chemoradiotherapy for EMC in the nasal cavity.

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