Caner ÇAKIR, Vakkas KORKMAZ, Çiğdem KILIÇ, Dilek YÜKSEL, Mehmet ÜNSAL, Betül TOKGÖZ, Fatih KILIÇ, Sevgi KOÇ, Fulya KAYIKÇIOĞLU, Taner TURAN

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Uterusa sınırlı karsinosarkom ve grade 3 endometrioid endometrium kanserinin klinikopatolojik ve sağkalım analizlerinin karşılaştırılması

Amaç: Grade 3 endometrioid endometrium kanseri (G3ECC) ve karsinosarkom (KS), ESMO-ESGO-ESRTO’un 2015’de yayınladığı konsensüsunda endometrium kanseri olguları içinde aynı risk grubunda yer alsa da, bu histolojik tiplerin biyolojik davranışları farklıdır. Bu çalışmada G3ECC olguları ile uterusa sınırlı KS vakalarının klinik sonuçlar ve sağkalım analizleri açısından karşılaştırılması amaçlandı.
Anahtar Kelimeler:

Endometrioid endometrium kanseri, grade 3, karsinosarkom, yüksek risk, endometrial kanser, rekürrens

Comparison of clinicopathological and survival analysis of uterus confined carcinosarcoma and grade 3 endometrioid endometrium cancer

Aim: Although Grade 3 endometrioid endometrial cancer (G3ECC) and carcinosarcomas (CS) are included in the same risk group among endometrial cancer cases in the consensus published by ESMO-ESGO-ESRTO in 2015, the biological behaviors of these histological types are different. In this study, we aimed to compare grade 3 endometrioid endometrial cancer cases with carcinosarcoma cases limited to the uterus in terms of clinical results and survival analysis.Material and Methods: Grade 3 endometrioid endometrial cancer (G3 ECC) cases (n = 67) in which the disease is limited to the uterus and uterine limited CS cases (n = 54) were compared in terms of clinical results and survival analysis.Results: Despite the limited disease in the uterus, survival was significantly worse in patients with carcinosarcoma. While recurrence was 10.5% in G3ECC, this rate was found as 27.8% in CS (p = 0.011).Conclusion: Carcinosarcomas may have a worse prognosis than G3 endometrioid endometrial cancers even in the early stages.
Keywords:

Endometrioid endometrium cancer, Grade 3, carcinosarcoma, high risk, endometrial cancer, recurrence,

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Türk Kadın Sağlığı ve Neonatoloji Dergisi-Cover
  • Başlangıç: 2019
  • Yayıncı: Sağlık Bilimleri Üniversitesi Etlik Zübeyde Hanım Kadın Hastalıkları Eğitim ve Araştırma Hastanesi
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