Senem ARDA DÜZ, Görkem TUNCAY, Abdullah KARAER

Polikistik over sendromunda anti-mullerian hormon ve vitamin D düzeylerinin değerlendirilmesi

Amaç: Bu çalışmanın amacı polikistik over sendromu (PKOS) ile serum anti-müllerian hormon (AMH) ve D vitamini düzeyleri arasında klinik açısından bir ilişki olup olmadığının araştırılmasıdır.Gereç ve yöntem: Şubat 2016 ile Kasım 2016 tarihleri arasında 44 PKOS tanısı almış hasta ile normal menstrüel siklusları olan 44 hasta çalışmaya dahil edilmiştir. Hormonal parametreler, glukoz metabolizması parametreleri, klinik bulgu ve belirtiler, serum D vitamini ve AMH düzeyleri değerlendirilmiştir. Bulgular: AMH düzeyleri, hirsutism skorları ve tokluk kan şekerleri iki grup arasında istatistiksel olarak anlamlı bir şekilde farklıydı. AMH ile luteinize edici hormon (LH)/folikül stimule edici hormon (FSH) oranı, insulin direnci homeostatik model değerlendirmesi (HOMA-IR), açlık kan şekeri ve hirsutizm skorları arasında pozitif korelasyon tespit edildi. PKOS grubunda serum AMH düzeyleri kontrol grubuna göre anlamlı olarak daha yüksek saptandı. Serum D vitamini seviyeleri her iki grupta düşük saptanmakla birlikte gruplar arasında D vitamin düzeyleri açısından fark yoktu. Sonuç: Serum AMH seviyeleri ile LH/FSH oranı, hirsutism skoru, HOMA-IR ve açlık insulin düzeyleri arasında pozitif korelasyon bulunmuştur. Daha yüksek AMH seviyelerine sahip olan hastaların, PKOS olup da düşük AMH seviyesine sahip olanlara göre daha hiperandrojenik olduğu bulunmuştur. Bunların yanı sıra gruplar arasında, vitamin D düzeyleri açısından istatistiksel olarak anlamlı fark saptanmamıştır.

Anahtar Kelimeler:

anti-müllerian hormon, hisutizm, hiperandrojenizm, polikistik over sendromu, vitamin D

The determination of anti-mullerian hormone and vitamin D serum levels in polycystic ovary syndrome

Aim: This study aimed to determine whether there is a relationship between serum anti-mullerian hormone (AMH) and vitamin D levels and the severity of polycystic ovary syndrome (PCOS). Material and method: Forty-four women with PCOS and forty-four controls with regular ovulatory menstrual cycles were included in this study between February 2016 and November 2016. Hormonal parameters, glucose metabolism parameters, clinical signs, and symptoms and serum AMH and vitamin D levels were determined. Results: AMH levels, hirsutism scores, and postprandial glucose levels were significantly different between the two groups. There were statistically significant positive correlations between AMH and luteinizing hormone (LH)/follicle stimulating hormone (FSH) ratio, homeostatic model assessment of insulin resistance (HOMA-IR), fasting glucose levels, and hirsutism scores. Serum AMH levels were significantly higher in women with PCOS compared to controls. The levels of vitamin D were found low in both groups, and there was no statistically significant difference between the two groups in vitamin D levels.Conclusion: There were positive correlations between AMH levels and LH/FSH ratio, hirsutism scores, HOMA-IR, and the fasting insulin. The patients with higher AMH levels were more hyperandrogenic compared to patients with PCOS who have lower AMH levels. Nevertheless, there was no statistically significant difference between the two groups in vitamin D levels.

Keywords:

anti-mullerian hormone, Hirsutism, Hyperandrogenism, Polycystic ovary syndrome, Vitamin D,

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