Sedanter erkeklerde egzersize bağlı iskelet kası zorlanmasının enerji düzenleyici hormonlar olan irisin ve nesfatin-1 üzerine olan etkileri

Amaç: Egzersiz, vücut enerji metabolik sistem aktivitesini, mekanik aktiviteyi veya hormonal etkileri artırarak düzenleyen önemli bir yöntemdir. Bu çalışmadaki amacımız aerobik egzersizin enerji tüketimini artıran irisin hormonu ve enerji alımını baskılayan nesfatin-1 hormonu üzerine etkilerini ve bunların kas hasarı artışını yansıtan kreatin kinase CK ile ilişkisini incelemektir.Yöntem: Toplam 30 sağlıklı, sedanter erkek katılımcıya anaerobik eşiklerinde 30 dakika aerobik koşu egzersizi uygulandı. Egzersiz öncesi ve sonrası kan örnekleri alındı. Serum irisin, nesfatin-1 ve CK analiz edildi. Bulgular: Tüm katılımcılarda egzersiz süresince serum irisin ve CK düzeyleri artış gösterdi %16.4 ve %25.7 sırası ile . Ortalama değerler istatistiksel olarak anlamlı artış göstermesine rağmen nesfatin-1 düzeyi tüm katılımcılarda artış göstermedi %12.1 . Irisin ve CK seviyelerindeki artışlar arasında pozitif yönde istatistiksel olarak anlamlı korelasyon sapyandı. Sonuç: Egzersize bağlı iskelet kası aktivitesi CK ve irisin seviyelerinde artışa neden olabilir. Nesfatin-1 egzersize bağlı hormon gibi görünmeyebilir ve artmış kas aktivitesi ile korelasyon göstermemektedir. Orta yoğunluktaki aerobik egzersiz metabolik hormonları değiştirerek vücut enerji düzenleyici sistemleri üzerinde faydalı etkiler sağlayabilir

Anahtar Kelimeler:

İrisin, nesfatin-1, kreatin kinaz, aerobik egzersiz

Impact of exercise induced skeletal muscle strain on energy regulatory hormones of irisin and nesfatin-1 in sedentary males

Objective: Exercise important tool to regulate body energy metabolic system activity by increasing mechanical activity or hormonal effects. In this study, we aimed to examine effects of aerobic exercise on levels of irisin, which increases energy expenditure and nesfatin-1, which suppress energy intake and their connection with CK, which reflects increased muscle injury.Methods: Total of 30 healthy sedentary male preformed 30 min of aerobic running exercise work intensity associated with their anaerobic threshold. Blood samples were taken before and after exercise. Serum irisin nesfatin-1 and creatine kinase CK were analysed.Results: During exercise serum irisin and CK levels increased in all subjects 16.4% and 25.7%, respectively . Despite the mean values increased statistically significant, nesfatin-1 levels did not increased in all subjects 12.1% . There was a positive statistically significant correlation between increase of irisin and CK levels. Conclusion: Consequently, exercise induced skeletal muscle activity may cause increase in CK and irisin levels. Nesfatin-1 hormones may not seem to be exercise-induced hormone and did not correlate with yoğunluktaki aerobik egzersiz metabolik hormonları değiştirerek vücut enerji düzenleyici sistemleri üzerinde faydalı etkiler sağlayabilir

Keywords:

Irisin, nesfatin-1, creatine kinase, aerobic exercise,

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