Merve ŞEKERLİ, Nil KILIÇ, Demet Cansaran DUMAN

Liken metabolitlerinin antikanser aktivite etkisinin moleküler düzeyde mekanizmaları

Tarih boyunca doğal ürünlerden elde edilen bileşenler; tıp, eczacılık ve biyoloji gibi pek çok alanda kullanılmıştır. Kanser alanında doğal moleküller model olarak kullanılarak yeni ve önemli bazı ticari ilaçlar elde edilmiştir. Sitotoksik ajanların geliştirilmesi için yapılan çalışmalar yeni antikanser ilaçlarının keşfi için de önemli bir adım olmuştur. Doğal bileşenlerin geniş yapısal çeşitliliği ve biyoaktivite potansiyeli moleküler modifikasyonlarla terapötik potansiyellerini geliştirmeye hizmet edebilir. Bu amaçla; özellikle son birkaç yılda liken kaynaklı bileşenlerin antikanser aktivitesiyle ilgili yapılan çalışmalar hızla artmaktadır. Likenler; fungus, alg veya siyanobakterilerin bir araya gelerek oluşturdukları simbiyotik birlikteliklerdir. Likenler, çoğu kendine özgü çok fazla sayıda sekonder metabolit sentezlerler. Liken sekonder metabolitleri antiviral, antitümör, antibakteriyel, antiherbivor ve antioksidan olmak üzere pek çok biyolojik aktiviteye sahiptirler. Son yıllarda liken sekonder metabolitlerinin tıbbi ve biyoteknolojik alanda dikkat çeken en önemli özelliklerinden birisi de kanser tedavisinde aday molekül olabileceklerine dair sonuçların ortaya çıkmasıdır. Kanserin moleküler temelleri ve özellikle apoptoz yolağı ile ilişkili süreçlerin aydınlatılması kanser tedavisinde alternatif ilaçların bulunmasında büyük bir yarar sunacağı düşünülmektedir. Bu derlemede; liken sekonder metabolitleri, kanser tedavisinde etkin kullanım potansiyelleri ve kanserleşme sürecinde özellikle apoptoz yolağı başta olmak üzere tüm moleküler mekanizmalar hakkında bilgi sunulmaktadır

Anahtar Kelimeler:

liken sekonder metabolitleri, kanser, moleküler mekanizmalar

The Molecular Mechanisms of the effect of anticancer activity on lichen metabolites

The components obtained from natural products have been used in many fields such as medicine, pharmacy and biology throughout the history. Some new and important commercial drugs have been obtained by using as a natural molecule model in the cancer field. Studies for the development of cytotoxic agents were also an important step for the discovery of new anticancer drugs. Large structural diversity of natural components and their bioactivity potential may serve to improve the therapeutic potential with molecular modification. For this purpose, especially the number of studies on the anticancer activity of lichen components has increased in last few years. Lichens are symbiotic organisms compose of fungus and algae or cyanobacteria. Lichens synthesize a great variety of secondary metabolites spesifically. Lichen secondary compounds have many possible biological activities such as antiviral, antitumor, antibacterial and antiherbivore and antioxidants. In recent years, one of the most important features of lichen secondary metabolites in medical and biotechnological field is the emmergance of results that maybe candidate molecules in the treatment of cancer. Elucidation of the molecular basis of cancer related processes and especially apoptosis pathway ilaçların bulunmasında büyük bir yarar sunacağı düşünülmektedir. Bu derlemede; liken sekonder metabolitleri, kanser tedavisinde etkin kullanım potansiyelleri ve kanserleşme sürecinde özellikle apoptoz yolağı başta olmak üzere tüm moleküler mekanizmalar hakkında bilgi sunulmaktadır

Keywords:

lichen secondary metabolites, cancer, molecular mechanisms,

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