İmmün sistemi baskılanmış hastada Listeria monocytogenese baglı septisemi ve menenjitin tedavisnde seftriaksondan ampisilin'e erken geçiş

Listeria monocytogenes is an important pathogen that may cause infection in the elderly and in immunocompromised patients with predisposing conditions. It can be an important cause of lifethreatening bacteremia and meningoencephalitis in immunocompromised individuals. In this report, it was described a case of sepsis and menegititis caused by L. monocytogenes in a 39-year-old female with adenoid cystic carcinoma of the larynx. L. monocytogenes identification was performed at the species level using matrix-assisted laser desorption ionization-time of flight mass spectrometry MALDI-TOF MS, Bruker Daltonics, Germany . The patient was treated with an early switch therapy from ceftriaxone to ampicillin. This report indicates that early detection and treatment of Listeria sepsis and meningitis are important to obtain a better prognosis

Anahtar Kelimeler:

Listeria monocytogenes, meningitis, septicemia, MALDI TOF MS

Early switch therapy from ceftriaxone to ampisilin in an immunosuppressed patient with Listeria monocytogenes septicemia and meningitis

Listeria monocytogenes, yaşlılarda ve predispozan koşulları olan bağışıklık sistemi baskılanmış hastalarda enfeksiyona neden olabilecek önemli bir patojendir. Bu bakteri, bağışıklık sistemi baskılanmış kişilerde hayatı tehdit eden bakteriyemi ve meningoensefalitin önemli bir nedeni olabilir. Bu raporda, larenks adenoid kistik karsinomu olan 39 yaşındaki bir kadın hastada L. monocytogenes’in etken olduğu sepsis ve menenjit olgusu tanımlandı. L. monocytogenes’in tür düzeyinde tanımlanması matrix-assisted laser desorption and ionization timeof-flight mass spectrometry MALDI-TOF MS, Bruker, Almanya ile yapıldı. Hasta tedavide seftriaksondan ampisiline erken geçiş ile tedavi edildi. Bu rapor, Listeria sepsis ve meninjitinin erken saptanmasının ve tedavisinin, daha iyi bir prognoz elde edilmesindeki önemini işaret etmektedir

Keywords:

Listeria monocytogenes, menenjit, sepsis, MALDI TOF MS,

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