Fazila Atakan ERKAL, Nevgün Sepin ÖZEN, Mestan EMEK, Şenay Tuğlu ATAMAN, Melek YALÇINKAYA, Nihal AKSOY, Murat ÖZDEMİR

Hepatit B'li Hastalarda Artmış Ortalama Trombosit Hacmi, Eritrosit Dağılım Genişliği ve Trombosit / Eritrosit Dağılım Genişliği Oranı

Amaç: Hepatit B virüsü tüm dünyada önemli bir morbidite ve mortalite nedenidir. Son yıllardaki çalışmalarda kronik hepatit B’li hastalarda rutin hematolojik parametrelerden olan ortalama trombosit hacmi MPV ve eritrosit dağılım genişliği RDW seviyeleri sağlıklı kişilere göre anlamlı olarak yüksek bulunmuştur. Bu çalışmada Hepatit B yüzey antijeni HBsAg pozitif olgularda MPV, RDW ve RDW/Trombosit PLT eritrosit dağılım genişliği/trombosit oranı RPR ilişkisinin araştırılması amaçlanmıştır.Yöntem: 2011-2012 yılları arasında Antalya Halk Sağlığı Laboratuvarı’na başvuran hastalar retrospektif olarak incelemeye alındı. HBsAg pozitif olarak saptanan ve yaşları 17-82 arasında değişen 349’u kadın ve 213’ü erkek olmak üzere toplam 562 hasta çalışmaya alındı. Aynı dönemde yaklaşık 3:1 hasta/kontrol oranında sağlıklı kişilerin yaş ve cinsiyet ile eşleşen kontrol grubu oluşturuldu. Kontrol grubu, yaşları 18-76 arasında değişen 121 kadın ve 80 erkekten oluşturuldu. Hastaların eş zamanlı olarak alanin aminotransferaz ALT , aspartat aminotransferaz AST , PLT, MPV, RDW ve RPR düzeyleri incelendi. Results: Average age in the HBsAg positive group was found to be 42.07 ± 12.71 years. HbsAg negative control group had mean age of 41.21 ± 13.15 years. There was no statistically difference of age among patient and control groups p=0.367 . AST and ALT values in HBsAg positive patients were significantly higher than the control group p

Anahtar Kelimeler:

HBsAg, MPV, RDW, RPR oranı

Increased Mean Platelet Volume, Red Blood Cell Distribution Width and Platelet/ Red Blood Cell Distribution Width in Patients With Hepatitis B.

Objective: Hepatitis B virus is a major cause of morbidity and mortality worldwide. In chronic hepatitis B patients, routine hematological parameters such as Mean Platelet Volume MPV , Red Cell Distribution Width RDW levels were found significantly higher than healthy persons in recent reports. The present study aimed to investigate the relationship of MPV, RDW and RDW / platelet PLT RPR in Hepatitis B surface antigen HBsAg positive cases.Methods: Patients were evaluated retrospectively between 2011-2012 years in Public Health Laboratory, Antalya. 562 cases of HBsAg positive patients of which were 349 women and 213 men aged between 17-82 years old enrolled the study. During the same period control group were recruited from healthy persons at patient/control ratio of approximately 3:1 with matching age and sex. Control group was consisted of 121 women and 80 men aged between 18-76 years old . At the same time alanine aminotransferase ALT , aspartate aminotransferase AST , PLT, MPV, RDW and RPR levels of patients were investigated

Keywords:

HBsAg MPV, RDW, RPR oranı, Hepatit B,

PDF

___

1. Turhan O, Coban E, Inan D, Nevzat Y.A. Increased mean platelet volume in chronic hepatitis B patients with inactive disease. Med Sci Monit, 2010; 16(4): CR202-5.
2. Ay P, Torunoglu MA, Com S, Cipil Z, Mollahaliloglu S et al. Trends of hepatitis B notification rates in Turkey, 1990 to 2012. Euro Surveill. 2013; 18(47): pii20636.
3. Ocama P, Opio CK, Lee WM: Hepatitis B virus infection: current status. Am J Med, 2005; 118(1413): 15-22.
4. Alizadeh Z, Milani S, Sharifi Z. Occult hepatitis B virus infection among Iranian Blood Donors: A preliminary study. Arach Iran Med, 2014; 17(2): 106-7.
5. Tong DY, Wang XH, Xu CF, Yang YZ, Xiong SD. Hepatitis B virus infection and coronary atherosclerosis: Results from a population with relatively high prevalence of hepatitis B virus. World J Gastroenterol, 2005; 11(9): 1292-6.
6. Targher G, Bertolini L, Padovani R, Rodella S, Arcaro G, Day C. Differences and similarities in early atherosclerosis between patients with nonalcoholic steatohepatitis and chronic hepatitis B and C. Journal of Hepatology, 2007; (46): 1126–32.
7. Joseph B. Chronic Infection and coronary atherosclerosis will the hypothesis ever really pan out?. J Am Coll Cardiol, 2011; 58(19): 2007-2009.
8. Epstein SE, Zhou YF, Zhu J. Infection and atherosclerosis: emerging mechanistic paradigms. Circulation, 1999; 100:20-28.
9. Chatzidimitriou D, Kirmizis D, Gavriilaki E, Chatzidimitriou M, Malisiovas N. Atherosclerosis and infection is the jury still not in? Future Microbiol, 2012; 7(10): 1217-30.
10. Murat SN, Duran M, Kalay N, Gunebakmaz O, Akpek M, Doger C et al. Relation between mean platelet volume and severity of atherosclerosis in patients with acute coronary syndromes. Angiology, 2013; 64(2): 131-6.
11. Arevalo-Lorido JC, Caretro-Gomez J, VillarVaca P. Mean platelet volume predicting carotid atherosclerosis in atherothrombotic ischemic stroke. Ir J Med Sci, 2012; 181(2): 179-83.
12. Spell DW, Jones DV Jr, Harper Wf, David Bassman J. The value of a complete blood counting in predicting cancer of colon. Cancer Detect Prev, 2004: 28(1): 37-42.
13. Sategna Guidetti C, Scaglione N, Martini S. Red cell distribution width as a marker of coeliac disease: a prospective study. Eur J Gastroenterol Hepatol, 2002 Feb; 14(2): 177-81.
14. Wen Y. High red blood cell distribution width is closely associated wiyh risk of carotid artery atherosclerosis in patients with hypertension. Exp Clin Cardiol, 2010; 15(3): 37-40.
15. Çetin M, Kocaman SA, Bostan M, Canga A, Cicek Y, Erdoğan T, et al. Red blood cell distribution width (RDW) and its association with coronary atherosclerotic burden in patients with stable angina pectoris. Eur J Gen Med, 2012; 9(1): 7-13.
16. Patel KV, Semba RD, Ferrucci L, Newman AB, Fried LP, Wallace RB, et al. Red blood cell distribution width and mortality in older adults: a metaanalysis. J Gerontol A Biol Sci Med Sci Mar, 2010: 65A(3): 258-65.
17. Zampieri FG, Ranzani OT, Sabatoski V, Heraldo PS, Hermes B, Neto LMC et al. An increase in mean platelet volume after admission is associates with higher mortality in critically ill patients. Annals of Intensive Care, 2014; 4: 20.
18. Baode C, Bo Y, Jian Z, Ying L, Chen Y. RDW to platelet ratio: a novel noninvasive index for predicting hepatic fibrosis and cirrhosis in chronic hepatitis B. PloS One, 2013 17; 8(7): e68780.
19. Zareifar S, Farahmand Far MR, Golfeshan F, Caohan N. Changes in platelet count and mean platelet volume during infectious and inflammatory disease and their correlation with ESR and CRP. J Clin Lab Anal, 2014; 28(3): 245-8.
20. Agarwal S, Kumar P, Kapadia S. Association between red cell distribution width (RDW) inflammatory markers and cardiovascular fitness in healthy adults. J Am Coll Cardiol, 2012; 59(13s1): E1179.
21. Cetinkaya E, Senol K, Saylam B, Tez M. Red cell distribution width to platelet ratio: New and promising prognostic marker in acute pancreatitis. World J Gastroenterol, 2014; 20(39): 14450-4.
22. Chatzidimitriou D, Kirmizis D, Gavriilaki E, Chatzidimitriou M, Malisiovas N. Atherosclerosis and infection is the jury still not in? Future Microbiol, 2012; 7(10): 1217-30.
23. Ishizaka N, Ishizaka Y, Takahashi E, Toda E, Hashimato H, Ohno M et al. Increased prevalence of carotid atherosclerosis in hepatit B virus carriers. Circulation, 2002; 105: 1028-30.
24. Ghotaslou R, Aslanabadi N, Ghojazadeh M. Hepatitis B virus infection and the risk of coronary atherosclerosis. Ann Acad Med Singapore, 2008; 37: 913-5.
25. Sung j, Song YM, Choi YH, Ebrahim S, Davey S.G. Hepatitis B seropozitivity and the risk of stroke and myocardial infarction. Stroke, 2007; 38: 1436-41.
26. Ekiz F, Yüksel O, Kocak E, Yılmaz B, Altınbaş A, Şentürk ÇS et al. Mean platelet volume as a fibrosis marker in patients with chronic hepatitis B. J Clin Lab Anal, 2011; 25(3): 162-5.
27. Cao Y, Hu Z-D, Hu C-J. An MLP Classifier for Prediction of HBV-Induced Liver Cirrhosis Using Routinely Available Clinical Parameters. Dis Markers, 2013; 35(6): 653-60.
28. Lou YF, Wang MY, Mao WL. Clinical usefulness of measuring red blood cell distribution width in patients with hepatitis B. Plos One May, 2012; 7 (5): e37644.