Primer variköz ven patogenezinde prolidazın rolü nedir?

Amaç: Bu çalışmada variköz ven gelişiminden sorumlu olduğu düşünülen prolidazın venlerdeki boyanması araştırıldı. Çalışma planı: Çalışmaya Klinik-Etyolojik-Anatomik-Patofizyolojik sınıflamasına göre C2-C4 variköz ven ameliyatı uygulanan 20 hastanın (10 erkek, 10 kadın, ort yaş 51.6±6.3 yıl; dağılım 32-62 yıl) primer variköz ven örneği ile 30 sağlıklı kontrolden (20 erkek, 10 kadın; ort. yaş 55.5±6.8 yıl; dağılım 38-70 yıl) koroner baypas için çıkarılan damar patolojisi örnekleri alındı. İmmünohistokimyasal boyama prolidaz antikor kullanılarak yapıldı. Her iki grubun immünohistokimyasal boyanması incelendi ve birbiri ile karşılaştırıldı. Bulgular: Her iki grup arasında demografik veriler açısından istatistiksel olarak anlamlı farklılık yoktu (p>0.05). Variköz örneklerin immünohistokimyasal analizinde prolidaz immün boyanması dört olguda (%20) negatif, 16 olguda (%80) pozitif idi. Sağlıklı venöz doku örneklerinde prolidaz immün boyanması 26 olguda (%86.7) negatif, dört olguda (%13.3) pozitif idi. Koroner baypas için çıkarılan sağlıklı venlerle variköz venlerin prolidaz immün boyanması açısından istatistiksel olarak karşılaştırılması anlamlı farklılık gösterdi (p

What is the role of prolidase in pathogenesis of primary varicose veins?

Background: This study aims to investigate the venous staining of prolidase which is thought to be responsible for varicose vein formation.Methods: The study included primary varicose vein samples of 20 patients (10 males, 10 females; mean age 51.6±6.3 years; range 32 to 62 years) who underwent C2-C4 varicose vein operation according to Clinical-Etiologic-Anatomic-Pathophysiologic classification and vein pathology samples removed for coronary bypass from 30 healthy controls (20 males, 10 females; mean age 55.5±6.8 years; range 38 to 70 years). Immunohistochemical staining was performed using prolidase antibody. Immunohistochemical staining of both groups was analyzed and compared with one another.Results: There was no statistically significant difference between both groups in terms of demographic data (p>0.05). In immunohistochemical analysis of varicose samples, prolidase immunostaining was negative in four cases (20%) and positive in 16 cases (80%). In healthy venous tissue samples, prolidase immunostaining was negative in 26 cases (86.7%) and positive in four cases (13.3%). Statistical comparison of healthy veins removed for coronary bypass and varicose veins with respect to prolidase immunostaining showed significant difference (p

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