2011

Kalp cerrahisinden sonra nörokognitif fonksiyon bozukluğu ve biyokimyasal belirteçler

Ameliyat sonrası kognitif fonksiyon bozukluğu, kalp ameliyatından sonra sık görülen bir nörolojik komplikasyondur. En sık görülen nörolojik komplikasyon olmasına karşın, patofizyolojisi halen tam olarak anlaşılamamıştır. Tanıda standartlaşmış klinik değerlendirme testlerinin olmaması ve uygulanan testlerin zaman alıcı olması, genellikle bu sorunun göz ardı edilmesine yol açmaktadır. Ayrıca tedavi maliyetinin de artışına neden olmaktadır. Bu nedenle, kognitif fonksiyon bozukluğunun kan örneklerinin analizi ile belirlenmesi, zaman kaybını azaltabilecektir. Bu makalede, S100ß ve nöron spesifik enolaz başta olmak üzere, ameliyat sonrası kognitif fonksiyon bozukluğunun belirlenmesinde kullanılan biyobelirteçler incelendi.

Neurocognitive dysfunction after cardiac surgery and biochemical markers

The postoperative cognitive dysfunction is typically neurologic complication after cardiac surgery. Although it is the most frequent neurologic complication, its pathophysiology is still poorly understood. The lack of standardized clinical evaluation tests in diagnosis and the fact that the applied tests are time-consuming usually makes it overlooked. It also increases treatment expenditures. Therefore, the determination of the cognitive dysfunction with the analysis of the blood samples may reduce the waste of time. In this article, we examine biomarkers, notably S100ß and neuron-specific enolase, which are used for the determination of the postoperative cognitive dysfunction.

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